Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels.
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Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugsStructural Basis for Pharmacology of Voltage-Gated Sodium and Calcium ChannelsModulation of the voltage sensor of L-type Ca2+ channels by intracellular Ca2+A structural basis for drug-induced long QT syndromeA genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channelsOpposite effects of a single IIIS5 mutation on phenylalkylamine and dihydropyridine interaction with L-type Ca2+ channelsThe VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic HomeostasisMolecular determinants of inactivation in voltage-gated Ca2+ channels.The L-type calcium channel in the heart: the beat goes onVerapamil block of T-type calcium channels.Subtype-selective reconstitution of synaptic transmission in sympathetic ganglion neurons by expression of exogenous calcium channels.Requirement for the synaptic protein interaction site for reconstitution of synaptic transmission by P/Q-type calcium channels.Probing the architecture of an L-type calcium channel with a charged phenylalkylamine: evidence for a widely open pore and drug trappingFunctional architecture of the inner pore of a voltage-gated Ca2+ channel.Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: role of inactivation.Structural basis of ion permeation gating in Slo2.1 K+ channels.Ca²⁺ channels and praziquantel: a view from the free worldThe role of region IVS5 of the human cardiac calcium channel in establishing inactivated channel conformation: use-dependent block by benzothiazepines.Block of the lymphocyte K(+) channel mKv1.3 by the phenylalkylamine verapamil: kinetic aspects of block and disruption of accumulation of block by a single point mutation.Binding mechanisms of 1,4-dihydropyridine derivatives to L-type calcium channel Cav1.2: a molecular modeling study.Nine L-type amino acid residues confer full 1,4-dihydropyridine sensitivity to the neuronal calcium channel alpha1A subunit. Role of L-type Met1188.Differential effects of Ca2+ channel beta1a and beta2a subunits on complex formation with alpha1S and on current expression in tsA201 cells.The IVS6 segment of the L-type calcium channel is critical for the action of dihydropyridines and phenylalkylamines.Analysis of the dihydropyridine receptor site of L-type calcium channels by alanine-scanning mutagenesis.The effect of deep pore mutations on the action of phenylalkylamines on the Kv1.3 potassium channel.Calcium channel block by (-)devapamil is affected by the sequence environment and composition of the phenylalkylamine receptor site.Extra- and intracellular action of quaternary devapamil on muscle L-type Ca(2+)-channels.Structural model for phenylalkylamine binding to L-type calcium channels.Molecular modeling study of isoindolines as L-type Ca(2+) channel blockers by docking calculations.Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.An amino acid residue whose change by mutation affects drug binding to the HERG channel.Molecular basis for Kv1.5 channel block: conservation of drug binding sites among voltage-gated K+ channels.Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil.A region in IVS5 of the human cardiac L-type calcium channel is required for the use-dependent block by phenylalkylamines and benzothiazepines.Molecular mechanism of diltiazem interaction with L-type Ca2+ channels.Molecular studies on the voltage dependence of dihydropyridine action on L-type Ca2+ channels. Critical involvement of tyrosine residues in motif IIIS6 and IVS6.Two amino acid residues in the IIIS5 segment of L-type calcium channels differentially contribute to 1,4-dihydropyridine sensitivity.Transfer of high sensitivity for benzothiazepines from L-type to class A (BI) calcium channels.Transfer of L-type calcium channel IVS6 segment increases phenylalkylamine sensitivity of alpha1A.
P2860
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P2860
Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Molecular determinants of high ...... ck of L-type calcium channels.
@en
type
label
Molecular determinants of high ...... ck of L-type calcium channels.
@en
prefLabel
Molecular determinants of high ...... ck of L-type calcium channels.
@en
P2093
P2860
P356
P1476
Molecular determinants of high ...... ck of L-type calcium channels.
@en
P2093
Catterall WA
Hockerman GH
Johnson BD
P2860
P304
22119-22122
P356
10.1074/JBC.270.38.22119
P407
P577
1995-09-01T00:00:00Z