Two SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase-activating protein.
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p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activitiesCdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.Protein-tyrosine phosphatase alpha acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelinationThe function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domainIndependent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and NckRas-GAP controls Rho-mediated cytoskeletal reorganization through its SH3 domain.A complex of p190RhoGAP-A and anillin modulates RhoA-GTP and the cytokinetic furrow in human cells.Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration.Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration.Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formationAdenosine diphosphate (ADP)-ribosylation of the guanosine triphosphatase (GTPase) rho in resting peripheral blood human T lymphocytes results in pseudopodial extension and the inhibition of T cell activation.Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap.Regulation of Rho GTPase activity at the leading edge of migrating cells by p190RhoGAP.Ras-GAP binding and phosphorylation by herpes simplex virus type 2 RR1 PK (ICP10) and activation of the Ras/MEK/MAPK mitogenic pathway are required for timely onset of virus growth.A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells.A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastomap120 GAP modulates Ras activation of Jun kinases and transformation.
P2860
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P2860
Two SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase-activating protein.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Two SH2 domains of p120 Ras GT ...... Rho GTPase-activating protein.
@en
type
label
Two SH2 domains of p120 Ras GT ...... Rho GTPase-activating protein.
@en
prefLabel
Two SH2 domains of p120 Ras GT ...... Rho GTPase-activating protein.
@en
P2093
P2860
P356
P1476
Two SH2 domains of p120 Ras GT ...... Rho GTPase-activating protein.
@en
P2093
McCormick F
Parsons SJ
Smithgall TE
P2860
P304
17947-17952
P356
10.1074/JBC.270.30.17947
P407
P577
1995-07-01T00:00:00Z