Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of alpha-conotoxin M1 selectivity.
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Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulatorsAssembly of human neuronal nicotinic receptor alpha5 subunits with alpha3, beta2, and beta4 subunitsEpibatidine activates muscle acetylcholine receptors with unique site selectivity.End-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseIdentification of critical residues in loop E in the 5-HT3ASR binding siteNuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonistSolution structure of alpha-conotoxin SIStructural Characterization of Binding Mode of Smoking Cessation Drugs to Nicotinic Acetylcholine Receptors through Study of Ligand Complexes with Acetylcholine-binding ProteinStructure-Function Elucidation of a New -Conotoxin, Lo1a, from Conus longurionisAllosteric activation mechanism of the cys-loop receptorsSex differences in the acetylcholine receptor kinetics of postnatal and denervated rat muscleThe emerging three-dimensional structure of a receptor. The nicotinic acetylcholine receptor.Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation.Photoactivatable alpha-conotoxins reveal contacts with all subunits as well as antagonist-induced rearrangements in the Torpedo californica acetylcholine receptor.Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.Conotoxins targeting nicotinic acetylcholine receptors: an overviewAcetylcholine receptor channels activated by a single agonist molecule.Electrostatic interactions regulate desensitization of the nicotinic acetylcholine receptor.Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranesMolecular interaction of α-conotoxin RgIA with the rat α9α10 nicotinic acetylcholine receptor.Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.α-Conotoxins Identify the α3β4* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells.Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR.Strategies for the development of conotoxins as new therapeutic leads.The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization.Number and locations of agonist binding sites required to activate homomeric Cys-loop receptorsFunctional relationships between agonist binding sites and coupling regions of homomeric Cys-loop receptorsInter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors.Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors.Insights into nicotinic receptor signaling in nicotine addiction: Implications for prevention and treatment.Curariform antagonists bind in different orientations to the nicotinic receptor ligand binding domain.Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits.Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain.Hydrophobic pairwise interactions stabilize alpha-conotoxin MI in the muscle acetylcholine receptor binding site.Pairwise electrostatic interactions between alpha-neurotoxins and gamma, delta, and epsilon subunits of the nicotinic acetylcholine receptor.Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models.Pairwise interactions between neuronal alpha7 acetylcholine receptors and alpha-conotoxin ImI.Subunit interface selectivity of the alpha-neurotoxins for the nicotinic acetylcholine receptor.Structural elements in alpha-conotoxin ImI essential for binding to neuronal alpha7 receptors.Identification of residues in the neuronal alpha7 acetylcholine receptor that confer selectivity for conotoxin ImI.
P2860
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P2860
Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of alpha-conotoxin M1 selectivity.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Molecular dissection of subuni ...... lpha-conotoxin M1 selectivity.
@en
type
label
Molecular dissection of subuni ...... lpha-conotoxin M1 selectivity.
@en
prefLabel
Molecular dissection of subuni ...... lpha-conotoxin M1 selectivity.
@en
P2093
P1433
P1476
Molecular dissection of subuni ...... lpha-conotoxin M1 selectivity.
@en
P2093
P304
P356
10.1016/0896-6273(95)90077-2
P407
P577
1995-07-01T00:00:00Z