Alzheimer's disease: genotypes, phenotypes, and treatments.
about
The generation and function of soluble apoE receptors in the CNSIdentification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1New Class of Inhibitors of Amyloid-beta Fibril Formation. IMPLICATIONS FOR THE MECHANISM OF PATHOGENESIS IN ALZHEIMER'S DISEASEbeta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation moduleFerritin light chain interacts with PEN-2 and affects γ-secretase activityAATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer diseaseMetabolic dysfunction in Alzheimer's disease and related neurodegenerative disordersSIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.SELDI ProteinChip® Array Technology: Protein-Based Predictive Medicine and Drug Discovery ApplicationsSoy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegansThe 2013 SFRBM discovery award: selected discoveries from the butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairmentTau-targeted treatment strategies in Alzheimer's diseaseHeritability and molecular genetic basis of electrodermal activity: a genome-wide association study.Inhibiting transthyretin conformational changes that lead to amyloid fibril formationReelin and apoE actions on signal transduction, synaptic function and memory formationBleomycin hydrolase is associated with risk of sporadic Alzheimer's diseaseThe pathogenic implication of abnormal interaction between apolipoprotein E isoforms, amyloid-beta peptides, and sulfatides in Alzheimer's diseaseThe glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's diseaseAbeta amyloid fibrils possess a core structure highly resistant to hydrogen exchangePresenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyMutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implicationPurification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR SpectroscopyCTCF is essential for up-regulating expression from the amyloid precursor protein promoter during differentiation of primary hippocampal neuronsPresenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1Common mechanism of ligand recognition by group II/III WW domains: redefining their functional classification.Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis.Amyloid precursor protein increases cortical neuron size in transgenic miceA ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's diseaseProbing the origins of increased activity of the E22Q "Dutch" mutant Alzheimer's beta-amyloid peptide.Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's diseaseThe human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates.Inhibition of fibril formation of Abeta by guanidiniocarbonyl pyrrole receptors.Biomarker identification in neurologic diseases: improving diagnostics and therapeutics.Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease.Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF Studies.Alzheimer's disease and the amyloid beta protein: What is the role of amyloid?Mathematical modeling for the pathogenesis of Alzheimer's disease.Reversibility of beta-amyloid self-assembly: effects of pH and added salts assessed by fluorescence photobleaching recoveryIncreased Amyloid Precursor Protein and Tau Expression Manifests as Key Secondary Cell Death in Chronic Traumatic Brain Injury.
P2860
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P2860
Alzheimer's disease: genotypes, phenotypes, and treatments.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Alzheimer's disease: genotypes, phenotypes, and treatments.
@en
type
label
Alzheimer's disease: genotypes, phenotypes, and treatments.
@en
prefLabel
Alzheimer's disease: genotypes, phenotypes, and treatments.
@en
P1433
P1476
Alzheimer's disease: genotypes, phenotypes, and treatments.
@en
P2093
P304
P356
10.1126/SCIENCE.275.5300.630
P407
P577
1997-01-01T00:00:00Z