Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.
about
Dishevelled and Wnt signaling: is the nucleus the final frontier?Modulation of LRP6-mediated Wnt signaling by molecular chaperone MesdCaprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylationDirect inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signalingA coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteinsAxin localizes to the centrosome and is involved in microtubule nucleationMolecular basis of Wnt activation via the DIX domain protein Ccd1Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signalingTiki1 is required for head formation via Wnt cleavage-oxidation and inactivationWnt/beta-catenin signaling and small molecule inhibitorsStructural basis of Wnt recognition by FrizzledWnt/beta-catenin signaling: components, mechanisms, and diseasesRegulation of the Wnt/β-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 OncoproteinsKeeping Wnt signalosome in check by vesicular trafficFrizzled homolog proteins, microRNAs and Wnt signaling in cancerRole of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunityDynamic association with donor cell filopodia and lipid-modification are essential features of Wnt8a during patterning of the zebrafish neuroectodermStructural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt SignalingStructure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complexPost-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signallingActivation of intracellular calcium by multiple Wnt ligands and translocation of β-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/β-catenin pathwaysPyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodelingNaked1 antagonizes Wnt signaling by preventing nuclear accumulation of β-cateninActivation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasisPrediction of structure of human WNT-CRD (FZD) complex for computational drug repurposingSpatio-temporal model of endogenous ROS and raft-dependent WNT/beta-catenin signaling driving cell fate commitment in human neural progenitor cellsN-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formationIdentification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signalingWnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodiesA dual-kinase mechanism for Wnt co-receptor phosphorylation and activationβ-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas.In vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryosCLAVATA2 forms a distinct CLE-binding receptor complex regulating Arabidopsis stem cell specificationWnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila.Differential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD.Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.Bone marrow mesenchymal stem cell-derived Wnt5a inhibits leukemia cell progression in vitro via activation of the non-canonical Wnt signaling pathway.The inorganic pyrophosphate transporter ANK preserves the differentiated phenotype of articular chondrocyte.
P2860
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P2860
Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Wnt signals across the plasma ...... s receptors, Frizzled and LRP.
@en
type
label
Wnt signals across the plasma ...... s receptors, Frizzled and LRP.
@en
prefLabel
Wnt signals across the plasma ...... s receptors, Frizzled and LRP.
@en
P356
P1433
P1476
Wnt signals across the plasma ...... s receptors, Frizzled and LRP.
@en
P2093
Liang Schweizer
P304
P356
10.1242/DEV.01318
P407
P577
2004-10-01T00:00:00Z