Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.
about
Growth suppression by p16ink4 requires functional retinoblastoma proteinArrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcriptionCyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4Regulation of p16CDKN2 expression and its implications for cell immortalization and senescenceHuman cyclin E, a nuclear protein essential for the G1-to-S phase transitionProtein p16 as a marker of dysplastic and neoplastic alterations in cervical epithelial cellsPPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a.The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.Expression of p16 gene and Rb protein in gastric carcinoma and their clinicopathological significanceTransgenic and knockout mice models to reveal the functions of tumor suppressor genes.pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears.p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer.CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations.High frequency of aberrant p16(INK4A) expression in human breast cancerMalignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivationMutations of cell cycle regulators. Biological and clinical implications for human neoplasia.Repression of cyclin D1 expression does not contribute to initiation or maintenance of cell transformation by adenovirus type 5 E1Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblastsAberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumour proliferation.Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas.Expression, deletion [was deleton] and mutation of p16 gene in human gastric cancerInduction of p16 during immortalization by HPV 16 and 18 and not during malignant transformation.Alterations of p16-pRb pathway and chromosome locus 9p21-22 in sporadic invasive breast carcinomas.Alterations of the p16-pRb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression.Loss of functional pRB is not a ubiquitous feature of B-cell malignanciesPredictive value of expression of p16INK4A, retinoblastoma and p53 proteins for the prognosis of non-small-cell lung cancers.High prevalence of p16 genetic alterations in head and neck tumoursRole of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell linesThe functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomasRapid induction of senescence in human cervical carcinoma cells.p16 as a diagnostic marker of cervical neoplasia: a tissue microarray study of 796 archival specimens.p16 immunostaining as a predictor of anal and cervical dysplasia in women attending a sexually transmitted infection clinic.Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.p16INK4A participates in a G1 arrest checkpoint in response to DNA damage.Induction of cyclins E and A in response to mitogen removal: a basic alteration associated with the arrest of differentiation of C2 myoblasts transformed by simian virus 40 large T antigen.p16/CDKN2 alterations and pRb expression in oesophageal squamous carcinoma.Concomitant presence of p16/cyclin-dependent kinase 4 and cyclin D/cyclin-dependent kinase 4 complexes in LNCaP prostatic cancer cell line.Loss of p16/INK4A protein expression in non-Hodgkin's lymphomas is a frequent finding associated with tumor progression.
P2860
Q24317567-7F7A9026-E703-48EE-B393-F22086BF45E1Q24554293-70B49961-EAC2-4D8C-99E9-55CC288B3B6BQ24644847-AE619DE5-0FB5-4B19-A2A8-49CE2DBAD56DQ24650807-829C30BC-239C-4198-AC30-229F5009CE67Q24652527-436F6C33-C0C4-4400-A70D-5FD6BD3E155CQ24792502-B8F6E4AC-2B67-44B5-9F94-4697BB212FF4Q30476274-A959BD72-C7FF-43B9-854B-CF25816F6F6DQ33781484-615E9EFA-7F3C-443D-B6AA-F4A9AA60FAF6Q35010835-C0D62D09-1CAE-4E86-9D5D-B337F50C4879Q35155473-C5C1C0D1-2F2B-4B3E-9CBC-7649E4571AF9Q35565308-54859E66-523F-4CD2-965F-8CAF92EB87D0Q35586592-408E307D-9BBF-412F-A26B-C850E912847CQ35588555-96DFE013-C860-439D-B88A-32AE03E99178Q35753196-87AAEFB3-EDD3-4584-9F6F-2C6188394E91Q35782316-94068E35-3BB6-499E-923B-38BB6ABAFF19Q35788039-03285887-1C38-406C-A77C-DD8556C3B6F0Q35798342-9AC594D8-6661-4D59-8AC1-171CDEEE2568Q35872212-439183C4-DB54-4F9E-B497-5C8E5237624CQ35927191-90248AFB-5E43-4294-BAB8-20A2955743D8Q36115896-D74BC08F-7DFD-4A31-A06B-ACB8BA29F2FCQ36138681-8ACB4F02-4202-4C6B-935A-22740961BC96Q36397218-48D6EF6E-AA5A-4E12-814D-901AC9CEB012Q36421683-D95A1683-6DE1-4305-AA75-160786190A94Q36438383-7D13A985-4236-4E9B-8E0A-781FD6E2FAB6Q36445614-CF25BBA6-9485-479C-896B-949EDEAEBBE6Q36617740-F22625D1-4C6D-4B3A-9B9C-67DF6D4AFC75Q36619686-08F7DEC4-4414-4CE8-891F-813A41296144Q36619726-0BA0FB92-5A01-48C4-8AAC-BCDEFDEB4699Q36620199-8CA90A82-C1C1-417C-A577-17486259BB6DQ37038629-A923CC2F-D563-472F-B850-EABD8763D2CBQ37268828-6B6D4F6E-F612-4884-9620-8AAD4669E106Q37270641-C92EEE39-56FC-4DBD-9B90-8E8050BD38F5Q37417189-7ED5D1B3-86FB-43E7-9B17-335DE743C882Q37636887-B3AB5B2C-067F-471A-BB94-7F7B059154E4Q39631343-33A49AE6-52B6-47B5-BD15-70C7A9C9299AQ39878682-EDF33FE9-3859-4318-BBC8-918B2488E779Q40794448-E6692E64-43A8-4132-A7B1-CFB761024A3DQ41122189-58BBA3A6-9BC6-4A63-84B3-3D6DBDEB5AB0Q42850901-F6B4DD34-2D8B-421A-91EA-F79B4593AB7B
P2860
Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Differential expression and ce ...... nt kinase 4 inhibitor p16Ink4.
@en
type
label
Differential expression and ce ...... nt kinase 4 inhibitor p16Ink4.
@en
prefLabel
Differential expression and ce ...... nt kinase 4 inhibitor p16Ink4.
@en
P1433
P1476
Differential expression and ce ...... ent kinase 4 inhibitor p16Ink4
@en
P304
P407
P577
1994-11-01T00:00:00Z