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Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystalMitochondrial fatty acid oxidation in obesityDefinition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1ATen novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduriaStructural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domainRedesign of carnitine acetyltransferase specificity by protein engineeringMitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase and carnitine palmitoyltransferase II as potential control sites for ketogenesis during mitochondrion and peroxisome proliferationNovel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cellsCPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activityRegulation of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase protein by starvation, fat feeding, and diabetesThe effect of fasting/refeeding and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling ratsInhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residuesImpaired ketogenesis is a major mechanism for disturbed hepatic fatty acid metabolism in rats with long-term cholestasis and after relief of biliary obstructionCeramides and mitochondrial fatty acid oxidation in obesity.Natural trans-splicing in carnitine octanoyltransferase pre-mRNAs in rat liverNovel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation.Brown Adipose Tissue Bioenergetics: A New Methodological ApproachLocalization of an exonic splicing enhancer responsible for mammalian natural trans-splicing.Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profileAltered circadian rhythm and metabolic gene profile in rats subjected to advanced light phase shifts.Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition.Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes.(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects.Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1aHypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin.Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balanceCarnitine palmitoyltransferase 1C: From cognition to cancer.Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C (CPT1C) in male mice.Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance.Influence of etomoxir on the expression of several genes in liver, testis and heart.Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation.Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase promoter contains a CREB binding site that regulates cAMP action in Caco-2 cells.Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.Developmental changes in carnitine octanoyltransferase gene expression in intestine and liver of suckling rats.Short-term vitamin E treatment impairs reactive oxygen species signaling required for adipose tissue expansion, resulting in fatty liver and insulin resistance in obese mice.Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity.Structural (betaalpha)8 TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase.Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake.C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight.
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Dolors Serra Cucurull
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Dolors Serra Cucurull
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Dolors Serra Cucurull
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Dolors Serra Cucurull
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Dolors Serra Cucurull
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Dolors Serra Cucurull
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Dolors Serra Cucurull
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Dolors Serra Cucurull
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Dolors Serra
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Dolors Serra
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Dolors Serra Cucurull
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Dolors Serra Cucurull
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Dolors Serra Cucurull
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Dolors Serra Cucurull
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Dolors Serra
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P214
P950
P1053
L-3657-2014
P106
P1580
P21
P214
P31
P3829
P496
0000-0002-4936-4206
P734
P735
P7859
viaf-307161971