The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination.
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The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityAID targeting is dependent on RNA polymerase II pausing.Simultaneous in vitro characterisation of DNA deaminase function and associated DNA repair pathwaysActivation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.A coming-of-age story: activation-induced cytidine deaminase turns 10.AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.Error-prone DNA repair activity during somatic hypermutation in shark B lymphocytesActivation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complexKnown components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C biasControl of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences.Requirement of upstream Hfq-binding (ARN)x elements in glmS and the Hfq C-terminal region for GlmS upregulation by sRNAs GlmZ and GlmY.Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.Three-dimensional architecture of the IgH locus facilitates class switch recombination.Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID.Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regionsRegulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.Identification of core DNA elements that target somatic hypermutation.Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase.E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells.Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G.V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environmentEpigenetic reprogramming: is deamination key to active DNA demethylation?AID: a riddle wrapped in a mystery inside an enigma.Activation-induced cytidine deaminase in antibody diversification and chromosome translocation.Bach2 regulates AID-mediated immunoglobulin gene conversion and somatic hypermutation in DT40 B cells.AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice
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P2860
The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The transcription elongation c ...... nase-mediated DNA deamination.
@en
type
label
The transcription elongation c ...... nase-mediated DNA deamination.
@en
prefLabel
The transcription elongation c ...... nase-mediated DNA deamination.
@en
P2093
P2860
P356
P1476
The transcription elongation c ...... nase-mediated DNA deamination.
@en
P2093
Eleonora Market
Eva Besmer
F Nina Papavasiliou
P2860
P304
P356
10.1128/MCB.02375-05
P407
P577
2006-06-01T00:00:00Z