Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. - Wikidata - awgldk - TriplyDB

Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.

Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.

http://www.wikidata.org/entity/Q36228903

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Kinetic models reveal the in vivo mechanisms of mutagenesis in microbes and man AID targeting: old mysteries and new challenges AID and Apobec3G haphazard deamination and mutational diversity Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.Regulatory roles of natural antisense transcripts.AID and somatic hypermutation.A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation.Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination.Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5 Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.Mechanism and regulation of class switch recombination Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genes Bcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells.Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region AIDing antibody diversity by error-prone mismatch repair.DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID.Does antisense make sense of AID targeting?Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.Transcription induces strand-specific mutations at the 5' end of human genes.Identification of core DNA elements that target somatic hypermutation.Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase.G clustering is important for the initiation of transcription-induced R-loops in vitro, whereas high G density without clustering is sufficient thereafter Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes.Gene regulation and epigenetics in Friedreich's ataxia.Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA.R Loops in the Regulation of Antibody Gene Diversification.Evolution of coordinated mutagenesis and somatic hypermutation in VH5.Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.Mechanism of R-loop formation at immunoglobulin class switch sequences.II. Correlations between secondary structure stability and mutation frequency during somatic hypermutation.Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site.I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation.Stabilised DNA secondary structures with increasing transcription localise hypermutable bases for somatic hypermutation in IGHV3-23.Physiological Roles of DNA Double-Strand Breaks.Topoisomerase I and Genome Stability: The Good and the Bad.

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Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.

http://www.wikidata.org/entity/Q36228903

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Detection of chromatin-associa ...... ted for somatic hypermutation.

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Detection of chromatin-associa ...... ted for somatic hypermutation.

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type

label

Detection of chromatin-associa ...... ted for somatic hypermutation.

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Detection of chromatin-associa ...... ted for somatic hypermutation.

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prefLabel

Detection of chromatin-associa ...... ted for somatic hypermutation.

@ast

Detection of chromatin-associa ...... ted for somatic hypermutation.

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Journal of Experimental Medicine

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Detection of chromatin-associa ...... eted for somatic hypermutation

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Alberto Martin

http://www.w3.org/2001/XMLSchema#string

Diana Ronai

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Manxia Fan

http://www.w3.org/2001/XMLSchema#string

Matthew D Scharff

http://www.w3.org/2001/XMLSchema#string

Ziqiang Li

http://www.w3.org/2001/XMLSchema#string

P2860

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

Mfold web server for nucleic acid folding and hybridization prediction

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

Antisense transcription in the mammalian transcriptome

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181-190

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scholarly article

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10.1084/JEM.20062032

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1

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204

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Maria D Iglesias-Ussel

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6574558

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2118410

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