Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.
about
Kinetic models reveal the in vivo mechanisms of mutagenesis in microbes and manAID targeting: old mysteries and new challengesAID and Apobec3G haphazard deamination and mutational diversityActivation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.Regulatory roles of natural antisense transcripts.AID and somatic hypermutation.A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation.Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination.Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.Mechanism and regulation of class switch recombinationTopoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genesBcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells.Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch regionAIDing antibody diversity by error-prone mismatch repair.DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID.Does antisense make sense of AID targeting?Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regionsDeciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.Transcription induces strand-specific mutations at the 5' end of human genes.Identification of core DNA elements that target somatic hypermutation.Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase.G clustering is important for the initiation of transcription-induced R-loops in vitro, whereas high G density without clustering is sufficient thereafterRestricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes.Gene regulation and epigenetics in Friedreich's ataxia.Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA.R Loops in the Regulation of Antibody Gene Diversification.Evolution of coordinated mutagenesis and somatic hypermutation in VH5.Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.Mechanism of R-loop formation at immunoglobulin class switch sequences.II. Correlations between secondary structure stability and mutation frequency during somatic hypermutation.Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site.I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation.Stabilised DNA secondary structures with increasing transcription localise hypermutable bases for somatic hypermutation in IGHV3-23.Physiological Roles of DNA Double-Strand Breaks.Topoisomerase I and Genome Stability: The Good and the Bad.
P2860
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P2860
Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Detection of chromatin-associa ...... ted for somatic hypermutation.
@ast
Detection of chromatin-associa ...... ted for somatic hypermutation.
@en
type
label
Detection of chromatin-associa ...... ted for somatic hypermutation.
@ast
Detection of chromatin-associa ...... ted for somatic hypermutation.
@en
prefLabel
Detection of chromatin-associa ...... ted for somatic hypermutation.
@ast
Detection of chromatin-associa ...... ted for somatic hypermutation.
@en
P2093
P2860
P356
P1476
Detection of chromatin-associa ...... eted for somatic hypermutation
@en
P2093
Alberto Martin
Diana Ronai
Manxia Fan
Matthew D Scharff
Ziqiang Li
P2860
P304
P356
10.1084/JEM.20062032
P407
P577
2007-01-16T00:00:00Z