Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.
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A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signalingZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinityPhosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domainNon-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptorCloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 productionAnalysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonanceInteraction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signalingLck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cellsThe 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphataseA mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brainTyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cellsBinding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteinsRAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytesImplication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 productionSolution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptorThe two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytesSignaling via Shc family adapter proteinsCharacterization of Lnk. An adaptor protein expressed in lymphocytesT cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activationSos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptorsTyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activationGrb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interactionThe PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cellsInteractions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motifCloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinaseDownstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptorCD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage.Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life spanInteraction of Shc with Grb2 regulates association of Grb2 with mSOSThe proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cellsEvidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptorShc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIPp120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinaseEvidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signalingSyk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and VavLigation of the T-cell Antigen Receptor (TCR) Induces Association of hSos1, ZAP-70, Phospolipase C- 1, and Other Phosphoproteins with Grb2 and the -Chain of the TCRGRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.Role of the Lck Src homology 2 and 3 domains in protein tyrosine phosphorylation.
P2860
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P2860
Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.
@en
type
label
Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.
@en
prefLabel
Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.
@en
P2093
P356
P1433
P1476
Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.
@en
P2093
P304
P356
10.1126/SCIENCE.8235613
P407
P577
1993-11-01T00:00:00Z