Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates.
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Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?Role of farnesoid X receptor and bile acids in alcoholic liver diseaseAdrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondriaHuman NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathwaysDifferential role of ethanol and acetaldehyde in the induction of oxidative stress in HEP G2 cells: effect on transcription factors AP-1 and NF-kappaBInduction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptorContributions of human enzymes in carcinogen metabolismA role for protein phosphorylation in cytochrome P450 3A4 ubiquitin-dependent proteasomal degradationMicrosomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review.N-acetylcysteine attenuates alcohol-induced oxidative stress in the ratHepatic, metabolic, and nutritional disorders of alcoholism: from pathogenesis to therapy.CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitisPotential effects of L-NAME on alcohol-induced oxidative stressMethodology to assay CYP2E1 mixed function oxidase catalytic activity and its inductionIncreased oxidative DNA damage and hepatocyte overexpression of specific cytochrome P450 isoforms in hepatitis of mice infected with Helicobacter hepaticus.The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.CYP2E1 and oxidative liver injury by alcohol.CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury.Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies.Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations.Nrf2 and antioxidant defense against CYP2E1 toxicity.Influence of fat/carbohydrate ratio on progression of fatty liver disease and on development of osteopenia in male rats fed alcohol via total enteral nutrition (TEN).Central role of mitochondria in drug-induced liver injury.Psychophysiological stress: a significant parameter in drug pharmacokinetics.Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing.The assessment of an in-vitro model for evaluating the role of PARP in ethanol-mediated hepatotoxicity.Involvement of cytochrome P450 in cisplatin treatment: implications for toxicity.Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione.Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1.Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes.Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P450 2E1-dependent toxicity in HepG2 cells.Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1.Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells overexpressing human cytochrome P-4502E1.Cytochrome P-4502E1-dependent formation of trifluoroacetyl adducts from halothane by transduced HepG2 cells.Glycerol increases content and activity of human cytochrome P-4502E1 in a transduced HepG2 cell line by protein stabilization.The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: modulation by ERK, ROS, glutathione, and thioredoxin.Bystander signaling via oxidative metabolism.DNA damage, DNA repair, and alcohol toxicity--a review.Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductaseSNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance.
P2860
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P2860
Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Stable expression of human cyt ...... reactive oxygen intermediates.
@en
type
label
Stable expression of human cyt ...... reactive oxygen intermediates.
@en
prefLabel
Stable expression of human cyt ...... reactive oxygen intermediates.
@en
P2093
P356
P1433
P1476
Stable expression of human cyt ...... reactive oxygen intermediates.
@en
P2093
Cederbaum AI
Rashba-Step J
P304
P356
10.1021/BI00078A017
P407
P577
1993-07-01T00:00:00Z