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pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC)mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic stateA model of lysosomal pH regulationAntimicrobial Mechanisms of Macrophages and the Immune Evasion Strategies of Staphylococcus aureusLysosomal membrane proteins and their central role in physiologyThe Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole.TRPC6 channel translocation into phagosomal membrane augments phagosomal functionMycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cellFluoride-dependent interruption of the transport cycle of a CLC Cl−/H+ antiporterRegulation of lysosomal ion homeostasis by channels and transportersDiscovery of CLC transport proteins: cloning, structure, function and pathophysiologyReconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+High susceptibility to fatty liver disease in two-pore channel 2-deficient miceMembrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomesNiclosamide is a proton carrier and targets acidic endosomes with broad antiviral effectsLysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular ToxicitymTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPaseRecombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels.P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH.Expression and localization of CLC chloride transport proteins in the avian retina.Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae.Dysfunctional CFTR alters the bactericidal activity of human macrophages against Pseudomonas aeruginosa.Lysosomal physiology.Reactive-oxygen-species-mediated P. aeruginosa killing is functional in human cystic fibrosis macrophages.Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes.Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3).Pseudomonas aeruginosa-induced bleb-niche formation in epithelial cells is independent of actinomyosin contraction and enhanced by loss of cystic fibrosis transmembrane-conductance regulator osmoregulatory function.Vacuolar ATPase in phagosome-lysosome fusion.Nitric oxide releases Cl(-) from acidic organelles in retinal amacrine cells.Dental and Cranial Pathologies in Mice Lacking the Cl(-) /H(+) -Exchanger ClC-7The endocytic pathway in microglia during health, aging and Alzheimer's disease.Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells.Amino Acid Availability Modulates Vacuolar H+-ATPase AssemblyThe intracellular Ca²⁺ channels of membrane traffic.Null mutation of chloride channel 7 (Clcn7) impairs dental root formation but does not affect enamel mineralizationIntracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification.Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification.Soluble adenylyl cyclase is essential for proper lysosomal acidification
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
A cation counterflux supports lysosomal acidification.
@en
type
label
A cation counterflux supports lysosomal acidification.
@en
prefLabel
A cation counterflux supports lysosomal acidification.
@en
P2093
P2860
P50
P356
P1476
A cation counterflux supports lysosomal acidification.
@en
P2093
Alexandre Brodovitch
Benjamin E Steinberg
Kassidy K Huynh
Sabrina Jabs
P2860
P304
P356
10.1083/JCB.200911083
P407
P577
2010-06-21T00:00:00Z