about
Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligaseNovel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzymeDiscovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligaseSecond-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acidStructure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD)Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compoundsNew 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluationSpecificity Determinants for Lysine Incorporation in Staphylococcus aureus Peptidoglycan as Revealed by the Structure of a MurE Enzyme Ternary ComplexStructure Guided Development of Potent Reversibly Binding Penicillin Binding Protein InhibitorsStructure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurFDiscovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitorStructure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agentsProgestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moietySelective cytotoxicity of amidinopiperidine based compounds towards Burkitt's lymphoma cells involves proteasome inhibition6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligaseThe binding mode of second-generation sulfonamide inhibitors of MurD: clues for rational design of potent MurD inhibitorsCinnamic acid esters as potent inhibitors of fungal 17beta-hydroxysteroid dehydrogenase--a model enzyme of the short-chain dehydrogenase/reductase superfamily.Novel inhibitors of beta-ketoacyl-ACP reductase from Escherichia coli.Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus.Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor.New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria.Novel inhibitors of trihydroxynaphthalene reductase with antifungal activity identified by ligand-based and structure-based virtual screening.Novel 2-thioxothiazolidin-4-one inhibitors of bacterial MurD ligase targeting D-Glu- and diphosphate-binding sites.Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B.Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment libraryDevelopment of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives.Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.Novel toll-like receptor 4 (TLR4) antagonists identified by structure- and ligand-based virtual screening.Combined liquid chromatography-tandem mass spectrometry analysis of progesterone metabolites.Discovery of novel small-molecule compounds with selective cytotoxicity for Burkitt's lymphoma cells using 3D ligand-based virtual screening.Molecular dynamics to enhance structure-based virtual screening on cathepsin B.4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding site.Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase.New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.Synthesis and preliminary biological evaluations of (+)-isocampholenic acid-derived amides.Inhibitors of cathepsin B.Crystallization and preliminary X-ray analysis of a UDP-MurNAc-tripeptide D-alanyl-D-alanine-adding enzyme (PaMurF) from Pseudomonas aeruginosa.Cytoplasmic steps of peptidoglycan biosynthesis.Recent advances in the synthesis and applications of reduced amide pseudopeptides.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Stanislav Gobec
@ast
Stanislav Gobec
@en
Stanislav Gobec
@es
Stanislav Gobec
@nl
Stanislav Gobec
@sl
type
label
Stanislav Gobec
@ast
Stanislav Gobec
@en
Stanislav Gobec
@es
Stanislav Gobec
@nl
Stanislav Gobec
@sl
prefLabel
Stanislav Gobec
@ast
Stanislav Gobec
@en
Stanislav Gobec
@es
Stanislav Gobec
@nl
Stanislav Gobec
@sl
P106
P1153
23992294900
P21
P2456
P31
P496
0000-0002-9678-3083