Designed enediynes: a new class of DNA-cleaving molecules with potent and selective anticancer activity.
about
Chemistry and biology of natural and designed enediynesInspirations, discoveries, and future perspectives in total synthesisCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisSolution structure of a two-base DNA bulge complexed with an enediyne cleaving analogReversible Bergman cyclization by atomic manipulationReactions of an aromatic σ,σ-biradical with amino acids and dipeptides in the gas phase.DNA sequence recognition by the indolocarbazole antitumor antibiotic AT2433-B1 and its diastereoisomer.From nature to the laboratory and into the clinicSpecific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: a paradigm for the development of transcriptional antagonists.Direct comparison of solution and gas-phase reactions of the three distonic isomers of the pyridine radical cation with methanol.Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.Cell-specific regulation of apoptosis by designed enediynes.Recent developments in the design of bioreductive drugsGeneration and characterization of a distonic biradical anion formed from an enediynone prodrug in the gas phase.Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab.Transition metal-catalyzed couplings of alkynes to 1,3-enynes: modern methods and synthetic applications.Oxygen dependence of the cytotoxicity of the enediyne anti-tumour antibiotic esperamicin A1.Determination of the electron affinities of alpha- and beta-naphthyl radicals using the kinetic method with full entropy analysis. The C-H bond dissociation energies of naphthalene.Synthesis of a 1,3-Bridged Macrobicyclic Enyne via Chemoselective Cycloisomerization Using Palladium-Catalyzed Alkyne-Alkyne Coupling.Pyridine-enhanced head-to-tail dimerization of terminal alkynes by a rhodium-N-heterocyclic-carbene catalyst.The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme-prodrug therapies.Stereoselective preparation of conjugated (Z)-1,3-enynes by dehydration reactions of allenic bromohydrins and the use of the enynes in base-mediated tandem allylation ene-carbocyclization reactions with β-ketoesters.Highly Selective Olefin-Assisted PdII -Catalyzed Oxidative Alkynylation of Enallenes.Access to Acyclic Z-Enediynes by Alkyne Trimerization: Cooperative Bimetallic Catalysis Using Air as the Oxidant.Pd-catalyzed cross-coupling of terminal alkynes with ene-yne-ketones: access to conjugated enynes via metal carbene migratory insertion.One-pot Crabbé homologation-radical cascade cyclisation with memory of chirality.Variational fractional-spin density-functional theory for diradicals.Iron-Catalyzed gem-Specific Dimerization of Terminal Alkynes.Z-Selective (Cross-)Dimerization of Terminal Alkynes Catalyzed by an Iron Complex.Hydrido-Cobalt Catalyst as a Selective Tool for the Dimerisation of Arylacetylenes: Scope and Theoretical Studies
P2860
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P2860
Designed enediynes: a new class of DNA-cleaving molecules with potent and selective anticancer activity.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh
1992年學術文章
@zh-hant
name
Designed enediynes: a new clas ...... selective anticancer activity.
@en
type
label
Designed enediynes: a new clas ...... selective anticancer activity.
@en
prefLabel
Designed enediynes: a new clas ...... selective anticancer activity.
@en
P2093
P2860
P1433
P1476
Designed enediynes: a new clas ...... selective anticancer activity.
@en
P2093
P2860
P304
P356
10.1126/SCIENCE.256.5060.1172
P407
P577
1992-05-01T00:00:00Z