Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
about
The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolismLysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin SAlzheimer disease: new concepts on its neurobiology and the clinical role imaging will playThe neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer diseaseβ-Amyloid: the key peptide in the pathogenesis of Alzheimer's diseaseThe role of APP and BACE1 trafficking in APP processing and amyloid-β generationAmyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's diseaseAmyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegenerationRisk factor SORL1: from genetic association to functional validation in Alzheimer's diseaseAlzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzymeTrafficking and proteolytic processing of APPFe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor proteinThe intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid systemResveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicityMunc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processingPresenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membraneTargeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesisInteraction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide.Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomesNeuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain.A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein.In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing miceSynaptic and endosomal localization of active gamma-secretase in rat brain.Capillary electrophoresis for the study of affinity interactions.The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.Alzheimer's disease and the amyloid beta protein: What is the role of amyloid?The secretases: enzymes with therapeutic potential in Alzheimer disease.Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.Alternative polyadenylation of the amyloid protein precursor mRNA regulates translationInhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ(25-35)-induced neurotoxicity in cultured rat cortical neurons.The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.Alzheimer and beta-amyloid-treated fibroblasts demonstrate a decrease in a memory-associated GTP-binding protein, Cp20Therapeutic strategies for human amyloid diseases.Neuroplasticity in Alzheimer's disease.Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cellsCysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking.
P2860
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P2860
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
@en
type
label
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
@en
prefLabel
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
@en
P2093
P356
P1433
P1476
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
@en
P2093
P304
P356
10.1126/SCIENCE.1738847
P407
P577
1992-02-01T00:00:00Z