The role of beta 2-microglobulin in peptide binding by class I molecules.
about
Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I moleculesThe three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptideEvolution and comparative analysis of the bat MHC-I regionIdentification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's diseaseAn in vitro study of the dynamic features of the major histocompatibility complex class I complex relevant to its role as a versatile peptide-receptive moleculeHeat-aggregated noninfectious influenza virus induces a more balanced CD8(+)-T-lymphocyte immunodominance hierarchy than infectious virusDisparate interaction of peptide ligand with nascent versus mature class I major histocompatibility complex molecules: comparisons of peptide binding to alternative forms of Ld in cell lysates and the cell surface.Anchoring pockets in human histocompatibility complex leukocyte antigen (HLA) class I molecules: analysis of the conserved B ("45") pocket of HLA-B27Extracellular processing of peptide antigens that bind class I major histocompatibility moleculesEfficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide.Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cellsPositive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.Comparison of cell lines deficient in antigen presentation reveals a functional role for TAP-1 alone in antigen processing.Species-specific differences in chaperone interaction of human and mouse major histocompatibility complex class I molecules.The class I-b molecule Qa-1 forms heterodimers with H-2Ld and a novel 50-kD glycoprotein encoded centromeric to I-E betaPeptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains.A naturally processed mitochondrial self-peptide in complex with thymic MHC molecules functions as a selecting ligand for a viral-specific T cell receptor.Physical and functional association of the major histocompatibility complex class I heavy chain alpha3 domain with the transporter associated with antigen processing.Antigen-dependent and -independent Ca2+ responses triggered in T cells by dendritic cells compared with B cells.The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator.Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.Solution binding of an antigenic peptide to a major histocompatibility complex class I molecule and the role of beta 2-microglobulin.Serum proteases alter the antigenicity of peptides presented by class I major histocompatibility complex molecules.Analysis of the association of peptides of optimal length to class I molecules on the surface of cellsA recombinant, soluble, single-chain class I major histocompatibility complex molecule with biological activity.Major histocompatibility complex class I-specific and -restricted killing of beta 2-microglobulin-deficient cells by CD8+ cytotoxic T lymphocytes.Purification and characterization of a naturally processed hepatitis B virus peptide recognized by CD8+ cytotoxic T lymphocytes.Low temperature and peptides favor the formation of class I heterodimers on RMA-S cells at the cell surface.An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.A dominant negative mutant beta 2-microglobulin blocks the extracellular folding of a major histocompatibility complex class I heavy chain.Susceptibility to measles virus-induced encephalitis in mice correlates with impaired antigen presentation to cytotoxic T lymphocytes.Self tolerance of natural MHC class I ligands.Structural and functional analysis of beta2 microglobulin abnormalities in human lung and breast cancer.Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced.Specificity and flexibility in thymic selectionMonte Carlo study of the effect of beta 2-microglobulin on the binding cleft of the HLA-A2 complex.Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex.The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I.Ganglioside expression in tissues of mice lacking beta2-microglobulin.Computational characterization of residue couplings and micropolymorphism-induced changes in the dynamics of two differentially disease-associated human MHC class-I alleles.
P2860
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P2860
The role of beta 2-microglobulin in peptide binding by class I molecules.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
The role of beta 2-microglobulin in peptide binding by class I molecules.
@en
type
label
The role of beta 2-microglobulin in peptide binding by class I molecules.
@en
prefLabel
The role of beta 2-microglobulin in peptide binding by class I molecules.
@en
P2093
P356
P1433
P1476
The role of beta 2-microglobulin in peptide binding by class I molecules.
@en
P2093
P304
P356
10.1126/SCIENCE.2124002
P407
P577
1990-12-01T00:00:00Z