Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity.
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Expression and alternative splicing of the cytochrome P-450 CYP2A7A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 allelesPharmGKB summary: very important pharmacogene information for cytochrome P-450, family 2, subfamily A, polypeptide 6Molecular genetics of the human cytochrome P450 monooxygenase superfamilyIsolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomesAnalysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis.Identification of novel CYP2A6*1B variants: the CYP2A6*1B allele is associated with faster in vivo nicotine metabolism.Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes.Human and mouse liver coumarin 7-hydroxylases do not metabolize warfarin in vitro.CYP2A13-catalysed coumarin metabolism: comparison with CYP2A5 and CYP2A6.The inhibition of CYP enzymes in mouse and human liver by pilocarpineIdentification of the cytochrome P450 enzymes involved in the metabolism of cisapride: in vitro studies of potential co-medication interactionsMechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP 2A5 and human CYP 2A6Regulation of cytochrome P450 gene expression in human colon and breast tumour xenograftsCYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients?P450 and human cancer.Drug metabolism by tumours: its nature, relevance and therapeutic implications.Genetics of tobacco use.Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer.Inter-individual Variability of Coumarin 7-hydroxylation (CYP2A6 activity) in an Iranian PopulationThe role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalystQSAR of cytochrome inhibitors.Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer.Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins.Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.In vitro assessment of human cytochrome P450.The structure, function, and regulation of cytochrome P450 2A enzymes.Genetic polymorphisms in human drug-metabolizing enzymes: potential uses of reverse genetics to identify genes of toxicological relevance.Clinical importance of hepatic cytochrome P450 in drug metabolism.Inhibitory potency of 8-methoxypsoralen on cytochrome P450 2A6 (CYP2A6) allelic variants CYP2A6 15, CYP2A6 16, CYP2A6 21 and CYP2A6 22: differential susceptibility due to different sequence locations of the mutations.Comparison of the effects of inducers of cytochrome P450 on Mongolian gerbil and rat hepatic microsomal monooxygenase activities.A comparison of basal and induced hepatic microsomal cytochrome P450 monooxygenase activities in the cynomolgus monkey (Macaca fascicularis) and man.Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.Pyrazole-inducible proteins in DBA/2 mouse liver bind with high affinity to the 3'-untranslated regions of the mRNAs of coumarin hydroxylase (CYP2A5) and c-jun.Determination of coumarin metabolism in Turkish population.Gender difference in ifosfamide metabolism by human liver microsomes.More potent inhibition of human CYP2A6 than mouse CYP2A5 enzyme activities by derivatives of phenylethylamine and benzaldehyde.Expression of CYP2A3 mRNA and its regulation by 3-methylcholanthrene, pyrazole, and beta-ionone in rat tissues.Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6.
P2860
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P2860
Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Identification of the human li ...... umarin 7-hydroxylase activity.
@en
type
label
Identification of the human li ...... umarin 7-hydroxylase activity.
@en
prefLabel
Identification of the human li ...... umarin 7-hydroxylase activity.
@en
P2093
P2860
P356
P1433
P1476
Identification of the human li ...... umarin 7-hydroxylase activity.
@en
P2093
A W McLaren
L M Forrester
M J Glancey
P2860
P304
P356
10.1042/BJ2670365
P407
P577
1990-04-01T00:00:00Z