A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells.
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13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolismFatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel FunctionMethyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATPLipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipidsDeletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cellsBeta-cell alpha-ketoglutarate hydroxylases may acutely participate in insulin secretionAdenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretionMitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretionInsulin secretion and insulin-producing tumorsRegulation of insulin secretion: role of mitochondrial signalling.Regulation of islet beta-cell pyruvate metabolism: interactions of prolactin, glucose, and dexamethasone.High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation.A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic ß-cells.The extracellular redox state modulates mitochondrial function, gluconeogenesis, and glycogen synthesis in murine hepatocytes.The complex mechanism of glutamate dehydrogenase in insulin secretion.Banting lecture 2011: hyperinsulinemia: cause or consequence?Roles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity.Ca2+ responses to interleukin 1 and tumor necrosis factor in cultured human skin fibroblasts. Possible implications for Reye syndrome.Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets.Glucose-sensing mechanisms in pancreatic beta-cells.The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cellsMetabolome response to glucose in the β-cell line INS-1 832/13.A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogensMetabolic cycling in control of glucose-stimulated insulin secretionDiminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion.Differential modulation of L-type calcium channel subunits by oleate.Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells.Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells.Metabolomic analysis of pancreatic β-cell insulin release in response to glucose.Aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor-1{beta} plays a critical role in maintaining glucose-stimulated anaplerosis and insulin release from pancreatic {beta}-cells.The inhibitors of protein acylation, cerulenin and tunicamycin, increase voltage-dependent Ca(2+) currents in the insulin-secreting INS 832/13 cell.Stevioside Counteracts Beta-Cell Lipotoxicity without Affecting Acetyl CoA Carboxylase.Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moietiesGlucose stimulation of protein acylation in the pancreatic β-cellHypothalamic regulation of glucose-stimulated insulin secretion.Transcribing β-cell mitochondria in health and disease.
P2860
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P2860
A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
A role for malonyl-CoA in gluc ...... clonal pancreatic beta-cells.
@en
type
label
A role for malonyl-CoA in gluc ...... clonal pancreatic beta-cells.
@en
prefLabel
A role for malonyl-CoA in gluc ...... clonal pancreatic beta-cells.
@en
P2093
P1476
A role for malonyl-CoA in gluc ...... clonal pancreatic beta-cells.
@en
P2093
Glennon MC
Matschinsky FM
P304
21608-21612
P407
P577
1989-12-01T00:00:00Z