Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region.
about
Gene expression regulation by upstream open reading frames and human diseaseDepletion of GGA1 and GGA3 mediates postinjury elevation of BACE1Functional expression of human α9* nicotinic acetylcholine receptors in X. laevis oocytes is dependent on the α9 subunit 5' UTR.Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.The complex regulation of HIC (Human I-mfa domain containing protein) expression.The 5'-untranslated region of multidrug resistance associated protein 2 (MRP2; ABCC2) regulates downstream open reading frame expression through translational regulation.The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis.Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.Role of 5'- and 3'-untranslated regions of mRNAs in human diseases.PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Two novel DNA motifs are essential for BACE1 gene transcriptionAssociation of THBS1 rs1478605 T>C in 5'-untranslated regions with the development and progression of gastric cancer.Physical evidence supporting a ribosomal shunting mechanism of translation initiation for BACE1 mRNATranscriptional and post-transcriptional profile of human chromosome 21.MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjectsRoles of eIF2α kinases in the pathogenesis of Alzheimer's disease.The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and BeyondRNA binding protein/RNA element interactions and the control of translationSecondary RNA structure and nucleotide specificity contribute to internal initiation mediated by the human tau 5' leader.Basic leucine zipper family in barley: genome-wide characterization of members and expression analysis.Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region.Upstream open reading frames regulate the cell cycle-dependent expression of the RNA helicase Rok1 in Saccharomyces cerevisiae.PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model.β-Secretase activity in rat astrocytes: translational block of BACE1 and modulation of BACE2 expression.
P2860
Q27693182-F038FB3C-2527-4C3D-99C2-31BBECE8F9CFQ28594541-E346AD60-C63B-49B7-B53C-282D5B421E74Q30454356-02FEDC06-5B80-4ED2-A16B-6A27B755856BQ30486959-223E4246-A937-4C45-B3EA-8109F561B4AEQ33479130-1CD47840-9760-426E-819A-4F55D44BA7FAQ33613410-5B22482C-207A-455C-856D-78FDE761FDD6Q33722837-9143E6A7-5C1A-401D-9E88-EDE74FDF3BB2Q33844923-AC7F5777-9366-4DB4-A063-3350B324D5B7Q33903715-12993F31-B46E-4EA7-B19F-3DF63F062CDDQ33954924-7296CC3F-6D00-4954-A690-C439681FF23BQ34016479-0F79340D-0DDA-4286-BAA7-7CC90B70D5D6Q34024468-5927EBB0-ACE4-4A52-8762-06F55B1501C1Q34110227-CF63FF43-A17D-4E68-841D-10B195161EE0Q34431390-39885014-FEF5-4F63-873F-78E2303A53D1Q35662654-F30A1D0F-28E3-46B9-8320-D4E160A688C0Q36477544-766D8F25-F249-4AF2-9BEF-18364DF861E0Q37287384-8B6BE1E1-2425-4814-9FAD-96DC21CA02F9Q37596385-E7420F1E-4CC7-45A3-B0B7-975FD6FBB13FQ37718976-85030304-C721-4CDF-88E0-373BD93BAB57Q37987919-3FCF74E4-A53A-49E9-9EA3-0314650B7A29Q38019544-1E1F15B5-8B04-4ADC-AF5C-37756A8D7DD8Q39274764-0DBEE410-8ACC-4D2B-8826-B86A5B65DE9FQ39365815-06E3A978-200C-4F3B-A91D-91D032D1E26FQ40601806-9540FFAB-717F-4C0A-8E20-8A4EA3E91E0DQ42679404-D313D237-6F1D-49BF-B9DC-8FDB54E8D3C4Q43143483-5898803E-A3C1-4D22-B6CA-AF2340E0CAC4Q43567031-85E12796-1AC3-4077-B973-127EEF2944A9
P2860
Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Complex translational regulati ...... in the 5' untranslated region.
@en
type
label
Complex translational regulati ...... in the 5' untranslated region.
@en
prefLabel
Complex translational regulati ...... in the 5' untranslated region.
@en
P2860
P50
P356
P1476
Complex translational regulati ...... in the 5' untranslated region.
@en
P2093
Fabio Grohovaz
Rolf Thermann
P2860
P304
P356
10.1093/NAR/GKM191
P577
2007-04-16T00:00:00Z