Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.
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The Role of Chemokines in Shaping the Balance Between CD4(+) T Cell Subsets and Its Therapeutic Implications in Autoimmune and Cancer DiseasesBiased and g protein-independent signaling of chemokine receptorsLarge-scale production and protein engineering of G protein-coupled receptors for structural studiesNew insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptorsGaddum Memorial Lecture 2014: receptors as an evolving concept: from switches to biased microprocessorsConstitutively active rhodopsin and retinal diseaseMembrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCRCrystal structure of rhodopsin bound to arrestin by femtosecond X-ray laserCatalytic site conformations in human PNP by 19F-NMR and crystallography.Structural Features for Functional Selectivity at Serotonin ReceptorsInsights into congenital stationary night blindness based on the structure of G90D rhodopsinCrystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and CarvedilolAllostery and Substrate Channeling in the Tryptophan Synthase Bienzyme Complex: Evidence for Two Subunit Conformations and Four Quaternary StatesA genetically encoded 19F NMR probe for tyrosine phosphorylationHigh-Resolution NMR Determination of the Dynamic Structure of Membrane ProteinsMembrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR FunctionNovel Allosteric Modulators of G Protein-coupled ReceptorsStructural insights into ligand recognition and selectivity for classes A, B, and C GPCRsA functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2Function-specific virtual screening for GPCR ligands using a combined scoring methodCa(2+) ATPase Conformational Transitions in Lipid Bilayers Mapped by Site-directed Ethylation and Solid-State NMRTowards structural systems pharmacology to study complex diseases and personalized medicineG-Protein/β-Arrestin-Linked Fluctuating Network of G-Protein-Coupled Receptors for Predicting Drug Efficacy and Bias Using Short-Term Molecular Dynamics SimulationMicelles, Bicelles, and Nanodiscs: Comparing the Impact of Membrane Mimetics on Membrane Protein Backbone Dynamics.Site-specific fluorescent labeling to visualize membrane translocation of a myristoyl switch protein.NMR as a tool to investigate the structure, dynamics and function of membrane proteins.The power of mass spectrometry in structural characterization of GPCR signaling.Vibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors.The quiet renaissance of protein nuclear magnetic resonance.Advances in NMR structures of integral membrane proteins.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsSimulations of biased agonists in the β(2) adrenergic receptor with accelerated molecular dynamics.Structure-function of the G protein-coupled receptor superfamily.A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in ¹⁹F NMR studies of proteins.Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β₂-adrenergic receptors.Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotectionDiscovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptorGlobal fold of human cannabinoid type 2 receptor probed by solid-state 13C-, 15N-MAS NMR and molecular dynamics simulations.Solvent-accessibility of discrete residue positions in the polypeptide hormone glucagon by 19F-NMR observation of 4-fluorophenylalanine.
P2860
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P2860
Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.
@en
type
label
Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.
@en
prefLabel
Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.
@en
P2860
P50
P356
P1433
P1476
Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.
@en
P2093
Jeffrey J Liu
P2860
P304
P356
10.1126/SCIENCE.1215802
P407
P577
2012-01-19T00:00:00Z