T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
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The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genesLymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cellsT-bet, GATA-3, and Foxp3 expression and Th1/Th2 cytokine production in the clinical outcome of human infection with Leishmania (Viannia) speciesThe lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patternsPrognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-betInteraction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytesA novel method of modifying immune responses by vaccination with lipiodol-siRNA mixturesLinking obesity with type 2 diabetes: the role of T-betThe complex and central role of interferon-γ in graft-versus-host disease and graft-versus-tumor activityMechanisms underlying helper T-cell plasticity: implications for immune-mediated disease.An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiationT-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrowTCR-dependent translational control of GATA-3 enhances Th2 differentiationLarge-scale analysis of network bistability for human cancersCompound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cellsMolecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profileT-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγtThe transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gammaGATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2Direct regulation of Gata3 expression determines the T helper differentiation potential of NotchUnderstanding diseases by mouse click: the promise and potential of computational approaches in Systems BiologyDifferentiation of effector CD4 T cell populations (*)Downregulation of IL-13 gene transcription by T-bet in human T cells.GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.Multistable decision switches for flexible control of epigenetic differentiation.IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells.Cross-linking of CD80 on CD4+ T cells activates a calcium-dependent signaling pathwaySelective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.T-cell signaling regulated by the Tec family kinase, Itk.STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.Ectopic T-bet expression licenses dendritic cells for IL-12-independent priming of type 1 T cells in vitro.Effector T cell plasticity: flexibility in the face of changing circumstancesT-bet-dependent expression of osteopontin contributes to T cell polarization.Signaling pathways that lead to the silencing of the interleukin-4-producing potential in Th1 cells.Transcriptional modulation of the immune response by peroxisome proliferator-activated receptor-{alpha} agonists in autoimmune disease.Complex interactions of transcription factors in mediating cytokine biology in T cells.Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation.Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors.STAT1 signaling is essential for protection against Cryptococcus neoformans infection in mice.
P2860
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P248
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P2860
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
@en
type
label
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
@en
prefLabel
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
@en
P2093
P921
P356
P1433
P1476
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
@en
P2093
Eun Sook Hwang
Laurie H Glimcher
Pamela L Schwartzberg
Susanne J Szabo
P304
P356
10.1126/SCIENCE.1103336
P407
P577
2005-01-01T00:00:00Z