The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies.
about
Aggregation mechanism of an IgG2 and two IgG1 monoclonal antibodies at low pH: from oligomers to larger aggregates.Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange.Classification and characterization of therapeutic antibody aggregates.Phase transitions in human IgG solutions.A new tool for monoclonal antibody analysis: application of IdeS proteolysis in IgG domain-specific characterization.Phase separation in solutions of monoclonal antibodies and the effect of human serum albumin.Pathological crystallization of human immunoglobulins.Russell body phenotype is preferentially induced by IgG mAb clones with high intrinsic condensation propensity: relations between the biosynthetic events in the ER and solution behaviors in vitro.Remediating agitation-induced antibody aggregation by eradicating exposed hydrophobic motifs.Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.Elucidation of acid-induced unfolding and aggregation of human immunoglobulin IgG1 and IgG2 Fc.Avoiding antibody aggregation during processing: establishing hold times.Aqueous size-exclusion chromatographic separations of intact proteins under native conditions: Effect of pressure on selectivity and efficiency.Evaluation of effects of pH and ionic strength on colloidal stability of IgG solutions by PEG-induced liquid-liquid phase separation.
P2860
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P2860
The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
The use of native cation-excha ...... tion of monoclonal antibodies.
@en
type
label
The use of native cation-excha ...... tion of monoclonal antibodies.
@en
prefLabel
The use of native cation-excha ...... tion of monoclonal antibodies.
@en
P2093
P2860
P356
P1433
P1476
The use of native cation-excha ...... tion of monoclonal antibodies.
@en
P2093
Gerd R Kleemann
Hollis Lau
Ramil F Latypov
Shuang Chen
Yan Brodsky
P2860
P304
P356
10.1002/PRO.396
P577
2010-06-01T00:00:00Z