Unique inner pore properties of BK channels revealed by quaternary ammonium block.
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Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel.BK channels: multiple sensors, one activation gateCryo-EM structure of the open high-conductance Ca2+-activated K+ channelA charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels.Rapid intracellular TEA block of the KcsA potassium channel.Stereospecific binding of a disordered peptide segment mediates BK channel inactivation.Inhibition of large-conductance Ca2+-activated K+ channels by nanomolar concentrations of Ag+.Electrostatic influences of charged inner pore residues on the conductance and gating of small conductance Ca2+ activated K+ channels.Low resistance, large dimension entrance to the inner cavity of BK channels determined by changing side-chain volume.Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating.Selectivity filter gating in large-conductance Ca(2+)-activated K+ channels.Permeation and block of the Kv1.2 channel examined using brownian and molecular dynamics.Calcium ions open a selectivity filter gate during activation of the MthK potassium channelRing of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics.Control of single channel conductance in the outer vestibule of the Kv2.1 potassium channelState-dependent block of BK channels by synthesized shaker ball peptides.Intrinsic electrostatic potential in the BK channel pore: role in determining single channel conductance and block.Probing the geometry of the inner vestibule of BK channels with sugars.A residue at the cytoplasmic entrance of BK-type channels regulating single-channel opening by its hydrophobicity.Properties of the inner pore region of TRPV1 channels revealed by block with quaternary ammoniums.Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.N-terminal inactivation domains of beta subunits are protected from trypsin digestion by binding within the antechamber of BK channels.Molecular mechanisms of BK channel activation.Structural basis of ion permeation gating in Slo2.1 K+ channels.Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gatingIntersubunit coupling in the pore of BK channels.BK channel opening involves side-chain reorientation of multiple deep-pore residues.A slick, slack pathway through the pore.Mechanism of electromechanical coupling in voltage-gated potassium channels.The BK channel: a vital link between cellular calcium and electrical signaling.Molecular Determinants of BK Channel Functional Diversity and Functioning.An extracellular domain of the accessory β1 subunit is required for modulating BK channel voltage sensor and gate.On the mechanism of TBA block of the TRPV1 channel.Structural basis for gating the high-conductance Ca2+-activated K+ channel.Pore size matters for potassium channel conductance.Hydrophobic interaction between contiguous residues in the S6 transmembrane segment acts as a stimuli integration node in the BK channel.Keeping you healthy: BK channel activation by omega-3 fatty acidsState-independent block of BK channels by an intracellular quaternary ammonium.Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions.
P2860
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P2860
Unique inner pore properties of BK channels revealed by quaternary ammonium block.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Unique inner pore properties of BK channels revealed by quaternary ammonium block.
@en
type
label
Unique inner pore properties of BK channels revealed by quaternary ammonium block.
@en
prefLabel
Unique inner pore properties of BK channels revealed by quaternary ammonium block.
@en
P2860
P356
P1476
Unique inner pore properties of BK channels revealed by quaternary ammonium block.
@en
P2093
Richard W Aldrich
P2860
P356
10.1085/JGP.200409067
P577
2004-06-14T00:00:00Z