State-independent block of BK channels by an intracellular quaternary ammonium.
about
Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel.BK channels: multiple sensors, one activation gateThe voltage-dependent gate in MthK potassium channels is located at the selectivity filterLigand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.Structural correlates of selectivity and inactivation in potassium channels.Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+.Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix.Oxidative modulation of voltage-gated potassium channels.BK channel activation: structural and functional insightsA charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels.Stereospecific binding of a disordered peptide segment mediates BK channel inactivation.Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism.Single-channel kinetics of BK (Slo1) channels.Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating.Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implicationsSelectivity filter gating in large-conductance Ca(2+)-activated K+ channels.What keeps Kv channels small? The molecular physiology of modesty.Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and bariumCalcium ions open a selectivity filter gate during activation of the MthK potassium channelState-dependent block of BK channels by synthesized shaker ball peptides.Evidence for a deep pore activation gate in small conductance Ca2+-activated K+ channels.Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels.Gating at the selectivity filter in cyclic nucleotide-gated channels.A residue at the cytoplasmic entrance of BK-type channels regulating single-channel opening by its hydrophobicity.Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel.Closed state-coupled C-type inactivation in BK channels.Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.Transduction of voltage and Ca2+ signals by Slo1 BK channels.N-terminal inactivation domains of beta subunits are protected from trypsin digestion by binding within the antechamber of BK channels.Molecular mechanisms of BK channel activation.Structural basis of ion permeation gating in Slo2.1 K+ channels.A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid.Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gatingBK channel opening involves side-chain reorientation of multiple deep-pore residues.Evolutionarily conserved intracellular gate of voltage-dependent sodium channels.A slick, slack pathway through the pore.The BK channel: a vital link between cellular calcium and electrical signaling.The pore structure and gating mechanism of K2P channels.Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.
P2860
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P2860
State-independent block of BK channels by an intracellular quaternary ammonium.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
State-independent block of BK channels by an intracellular quaternary ammonium.
@en
type
label
State-independent block of BK channels by an intracellular quaternary ammonium.
@en
prefLabel
State-independent block of BK channels by an intracellular quaternary ammonium.
@en
P2860
P356
P1476
State-independent block of BK channels by an intracellular quaternary ammonium.
@en
P2093
Christina M Wilkens
Richard W Aldrich
P2860
P304
P356
10.1085/JGP.200609579
P577
2006-09-01T00:00:00Z