The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).
about
BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.The current view for the silencing of the spindle assembly checkpointBub3-BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomesStructural analysis of human Cdc20 supports multisite degron recognition by APC/CStructure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding SiteStructure of the mitotic checkpoint complexInsights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 ComplexRecruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.BubR1- and Polo-coated DNA tethers facilitate poleward segregation of acentric chromatids.Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.Spindle assembly checkpoint protein dynamics reveal conserved and unsuspected roles in plant cell division.Separating the spindle, checkpoint, and timer functions of BubR1Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase.Using default constraints of the spindle assembly checkpoint to estimate the associated chemical rates.Spindle checkpoint silencing: ensuring rapid and concerted anaphase onsetUnder arrest in mitosis: Cdc20 dies twice.The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis.BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex.Mutual regulation between the spindle checkpoint and APC/C.Centromere-tethered Mps1 pombe homolog (Mph1) kinase is a sufficient marker for recruitment of the spindle checkpoint protein Bub1, but not Mad1.Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC)Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint ArrestsMad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregationState of the APC/C: organization, function, and structure.Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast.A novel mutation in the N-terminal domain of Drosophila BubR1 affects the spindle assembly checkpoint function of BubR1.BUB1 and BUBR1: multifaceted kinases of the cell cycle.Structure, function and mechanism of the anaphase promoting complex (APC/C).Bub1 and BubR1: at the interface between chromosome attachment and the spindle checkpointStructural insights into anaphase-promoting complex function and mechanism.Panta rhei: the APC/C at steady state.Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms.Understanding the structural basis for controlling chromosome division.Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission YeastCdc20 control of cell fate during prolonged mitotic arrest: do Cdc20 protein levels affect cell fate in response to antimitotic compounds?BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing.Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe.
P2860
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P2860
The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The spindle checkpoint functio ...... ase-promoting complex (APC/C).
@en
type
label
The spindle checkpoint functio ...... ase-promoting complex (APC/C).
@en
prefLabel
The spindle checkpoint functio ...... ase-promoting complex (APC/C).
@en
P2093
P2860
P356
P1476
The spindle checkpoint functio ...... ase-promoting complex (APC/C).
@en
P2093
Anna Feoktistova
Julie Blyth
Jun-Song Chen
Karen M May
Matylda Sczaniecka
P2860
P304
23039-23047
P356
10.1074/JBC.M803594200
P407
P577
2008-06-13T00:00:00Z