Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation
about
Dual control by Cdk1 phosphorylation of the budding yeast APC/C ubiquitin ligase activator Cdh1Atomic structure of the APC/C and its mechanism of protein ubiquitination.The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylationSpatiotemporal regulation of the anaphase-promoting complex in mitosisThe spindle assembly checkpoint works like a rheostat rather than a toggle switchMolecular mechanism of APC/C activation by mitotic phosphorylation.TRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma.Endopolyploidization and flowering time are antagonistically regulated by checkpoint component MAD1 and immunity modulator MOS1.The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregationKinesin family member 4A: a potential predictor for progression of human oral cancerThe biochemistry of mitosisIntermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complexRev7/Mad2B plays a critical role in the assembly of a functional mitotic spindle.Panta rhei: the APC/C at steady state.Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms.Signalling dynamics in the spindle checkpoint response.The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Stable MCC binding to the APC/C is required for a functional spindle assembly checkpoint.Regulation of mitotic progression by the spindle assembly checkpointConformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling.Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitotic control.Aneuploidy in Cancer and Aging.The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.A Dynamical Model for Activating and Silencing the Mitotic CheckpointThe mitotic checkpoint complex (MCC): looking back and forth after 15 years.The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/CThe ABBA motif binds APC/C activators and is shared by APC/C substrates and regulatorsCatalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20.Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).The spindle-assembly checkpoint and the beauty of self-destruction.Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison.MAD1: Kinetochore Receptors and Catalytic Mechanisms.Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis
P2860
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P2860
Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation
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2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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name
Mad2 and the APC/C compete for ...... proper chromosome segregation
@ast
Mad2 and the APC/C compete for ...... proper chromosome segregation
@en
type
label
Mad2 and the APC/C compete for ...... proper chromosome segregation
@ast
Mad2 and the APC/C compete for ...... proper chromosome segregation
@en
prefLabel
Mad2 and the APC/C compete for ...... proper chromosome segregation
@ast
Mad2 and the APC/C compete for ...... proper chromosome segregation
@en
P2860
P356
P1476
Mad2 and the APC/C compete for ...... proper chromosome segregation
@en
P2093
Daisuke Izawa
P2860
P356
10.1083/JCB.201205170
P407
P577
2012-09-24T00:00:00Z