about
Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeastBub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis.Distinct chromosome segregation roles for spindle checkpoint proteins.Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption.Novel sfi1 alleles uncover additional functions for Sfi1p in bipolar spindle assembly and function.Budding yeast Cdc20: a target of the spindle checkpoint.Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.Checkpoint signalling: Mad2 conformers and signal propagationMad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpointNsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase BBub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes.The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint functionCPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.ERS1 a seven transmembrane domain protein from Saccharomyces cerevisiaeSpindle checkpoint silencing: ensuring rapid and concerted anaphase onsetThe awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling.The spindle checkpoint: structural insights into dynamic signalling.The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint ArrestsSorting of soluble ER proteins in yeastBub1 and the multilayered inhibition of Cdc20-APC/C in mitosis.Cdc28 activates exit from mitosis in budding yeast.Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis.The spindle checkpoint: how do cells delay anaphase onset?Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p.Getting down to the phosphorylated 'nuts and bolts' of spindle checkpoint signalling.Overcoming inhibition in the spindle checkpoint.Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function.Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission YeastKindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1.Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent mannerGeneration of a Spindle Checkpoint Arrest from Synthetic Signaling Assemblies.Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint"The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors.Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complexAn acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe.Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint ArrestShugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis.Correction: Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Kevin G Hardwick
@ast
Kevin G Hardwick
@en
Kevin G Hardwick
@es
Kevin G Hardwick
@nl
Kevin G Hardwick
@sl
type
label
Kevin G Hardwick
@ast
Kevin G Hardwick
@en
Kevin G Hardwick
@es
Kevin G Hardwick
@nl
Kevin G Hardwick
@sl
prefLabel
Kevin G Hardwick
@ast
Kevin G Hardwick
@en
Kevin G Hardwick
@es
Kevin G Hardwick
@nl
Kevin G Hardwick
@sl
P106
P21
P31
P496
0000-0002-6462-1047