about
Intrinsically disordered proteins in a physics-based worldEfficient Atomistic Simulation of Pathways and Calculation of Rate Constants for a Protein-Peptide Binding Process: Application to the MDM2 Protein and an Intrinsically Disordered p53 Peptide.Conformational frustration in calmodulin-target recognition.Transient Protein States in Designing Inhibitors of the MDM2-p53 InteractionMale germ cell apoptosis and epigenetic histone modification induced by Tripterygium wilfordii Hook FInsight into conformational change for 14-3-3σ protein by molecular dynamics simulation.Allosteric Autoinhibition Pathway in Transcription Factor ERG: Dynamics Network and Mutant Experimental Evaluations.Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100Molecular dynamics simulation of phosphorylated KID post-translational modification.Induced fit or conformational selection for RNA/U1A foldingff14IDPs force field improving the conformation sampling of intrinsically disordered proteins.Binding free energy landscape of domain-peptide interactions.A computational analysis of the binding model of MDM2 with inhibitors.Residual structures, conformational fluctuations, and electrostatic interactions in the synergistic folding of two intrinsically disordered proteins.Insight into the stability of cross-β amyloid fibril from VEALYL short peptide with molecular dynamics simulation.Atomistic mechanism of microRNA translation upregulation via molecular dynamics simulationsGlobal conformational selection and local induced fit for the recognition between intrinsic disordered p53 and CBPAnchoring intrinsically disordered proteins to multiple targets: lessons from N-terminus of the p53 protein.Direct observations of conformational distributions of intrinsically disordered p53 peptides using UV Raman and explicit solvent simulationsEnhancing the promiscuous phosphotriesterase activity of a thermostable lactonase (GkaP) for the efficient degradation of organophosphate pesticidesConformational selection and induced fit for RNA polymerase and RNA/DNA hybrid backtracked recognition.Synergistic Modification Induced Specific Recognition between Histone and TRIM24 via Fluctuation Correlation Network AnalysisStructural Exploration and Conformational Transitions in MDM2 upon DHFR Interaction from Homo sapiens: A Computational Outlook for Malignancy via Epigenetic Disruption.Dynamics Correlation Network for Allosteric Switching of PreQ1 RiboswitchSynergistic Allosteric Mechanism of Fructose-1,6-bisphosphate and Serine for Pyruvate Kinase M2 via Dynamics Fluctuation Network AnalysisCrystal Structure of StnA for the Biosynthesis of Antitumor Drug Streptonigrin Reveals a Unique Substrate Binding Mode.Microsecond simulations of mdm2 and its complex with p53 yield insight into force field accuracy and conformational dynamics.Allosteric mechanism of cyclopropylindolobenzazepine inhibitors for HCV NS5B RdRp via dynamic correlation network analysis.Coupled folding-binding in a hydrophobic/polar protein model: impact of synergistic folding and disordered flanks.Reconstructing the discontinuous and conformational β1/β3-loop binding site on hFSH/hCG by using highly constrained multicyclic peptides.Computational studies on the substrate interactions of influenza A virus PB2 subunit.Revealing the binding mode between respiratory syncytial virus fusion protein and benzimidazole-based inhibitors.Free energy evaluation of the p53-Mdm2 complex from unbinding work measured by dynamic force spectroscopy.New force field on modeling intrinsically disordered proteins.Conformation Dynamics of the Intrinsically Disordered Protein c-Myb with the ff99IDPs Force Field.Kink turn sRNA folding upon L7Ae binding using molecular dynamics simulations.The IDP-Specific Force Field ff14IDPSFF Improves the Conformer Sampling of Intrinsically Disordered Proteins.Characterizing the Free-Energy Landscape of MDM2 Protein-Ligand Interactions by Steered Molecular Dynamics Simulations.Selectivity Mechanism of ATP-Competitive Inhibitors for PKB and PKA.Interplay between binding affinity and kinetics in protein-protein interactions.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Binding induced folding in p53-MDM2 complex.
@en
type
label
Binding induced folding in p53-MDM2 complex.
@en
prefLabel
Binding induced folding in p53-MDM2 complex.
@en
P2860
P356
P1476
Binding induced folding in p53-MDM2 complex.
@en
P2093
Hai-Feng Chen
P2860
P304
P356
10.1021/JA0678774
P407
P50
P577
2007-02-16T00:00:00Z