about
Synapsis of DNA ends by DNA-dependent protein kinaseLymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombinationImmunoglobulin class switch recombination is impaired in Atm-deficient miceAssociation of SWAP-70 with the B cell antigen receptor complexMemory in the B-cell compartment: antibody affinity maturationKu and the Stability of the GenomeIgH chain class switch recombination: mechanism and regulationThe DNA repair protein yKu80 regulates the function of recombination enhancer during yeast mating type switchingSelective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elementsIgH class switching and translocations use a robust non-classical end-joining pathwayAID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switchingShifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctionsRole for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctionsReduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymesMsh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombinationMlh1 can function in antibody class switch recombination independently of Msh2Genomic instability in mice lacking histone H2AXExamination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification53BP1 is required for class switch recombination.Trans-chromosomal recombination within the Ig heavy chain switch region in B lymphocytes.Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Extreme growth failure is a common presentation of ligase IV deficiency.Immunoglobulin class switch recombination: will genetics provide new clues to mechanism?Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.The liaison of isotype class switch and mismatch repair: an illegitimate affair.Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70DNA polymerase mu, a candidate hypermutase?Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and developmentExpression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination.Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombinationSwitch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.High resolution analysis of the chromatin landscape of the IgE switch region in human B cellsIncreased ionizing radiation sensitivity and genomic instability in the absence of histone H2AXRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.In vivo and in vitro studies of immunoglobulin gene somatic hypermutation.Antibody diversification and selection in the mature B-cell compartment.Molecular mechanism of immunoglobulin class switch recombination.Molecular regulation of class switch recombination to IgE through epsilon germline transcription.
P2860
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P2860
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Ku80 is required for immunoglobulin isotype switching
@en
type
label
Ku80 is required for immunoglobulin isotype switching
@en
prefLabel
Ku80 is required for immunoglobulin isotype switching
@en
P2093
P2860
P356
P1433
P1476
Ku80 is required for immunoglobulin isotype switching
@en
P2093
A Nussenzweig
A Reichlin
R Casellas
R Wuerffel
P2860
P304
P356
10.1093/EMBOJ/17.8.2404
P407
P577
1998-04-01T00:00:00Z