Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediators
about
Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonistYD-3, a novel inhibitor of protease-induced platelet activationThe catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function.A molecular mechanism for signaling between seven-transmembrane receptors: evidence for a redistribution of G proteins.Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin.Differences between platelet phosphoinositide metabolism stimulated by thrombin or SFLLRN are not accounted for by interaction of thrombin with glycoprotein Ib.The cleaved peptide of the thrombin receptor is a strong platelet agonist.RGS10 Negatively Regulates Platelet Activation and Thrombogenesis.Protease-activated receptor 4: from structure to function and back again.The cellular basis of platelet secretion: Emerging structure/function relationships.Cellular consequences of thrombin-receptor activation.The human thrombin receptor gene and the 5q-syndrome.The protease-activated receptors and their cellular expression and function in blood-related cells.A trypsin-like platelet protease propagates protease-activated receptor-1 cleavage and platelet activation.TRAP induces more intense tyrosine phosphorylation than thrombin with differential ultrastructural features.Platelet-leukocyte aggregation induced by PAR agonists: regulation by nitric oxide and matrix metalloproteinases.A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B.Agonist concentration-dependent differential responsivity of a human platelet purinergic receptor: pharmacological and kinetic studies of aggregation, deaggregation and shape change responses mediated by the purinergic P2Y1 receptor in vitro.A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation.Differential secretion of blood platelet storage granules.Acceleration of Ca2+ ionophore-induced arachidonic acid liberation by thrombin without the proteolytic action toward the receptor in human platelets.Binding of thrombin to the G-protein-linked receptor, and not to glycoprotein Ib, precedes thrombin-mediated platelet activation.
P2860
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P2860
Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediators
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Thrombin-receptor agonist pept ...... et-derived secondary mediators
@en
type
label
Thrombin-receptor agonist pept ...... et-derived secondary mediators
@en
prefLabel
Thrombin-receptor agonist pept ...... et-derived secondary mediators
@en
P2093
P2860
P356
P1433
P1476
Thrombin-receptor agonist pept ...... et-derived secondary mediators
@en
P2093
P2860
P304
P356
10.1042/BJ3030391
P407
P478
303 ( Pt 2)
P577
1994-10-01T00:00:00Z