γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.
about
Structural biology of presenilin 1 complexesCurrent and future implications of basic and translational research on amyloid-β peptide production and removal pathwaysPresenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complexIndependent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models.Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase.Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulatorsγ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization.Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ.Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry.Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.Curcumin enhances vascular contractility via induction of myocardin in mouse smooth muscle cells.
P2860
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P2860
γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
γ-Secretase associated with li ...... β-carboxyl-terminal fragment.
@en
type
label
γ-Secretase associated with li ...... β-carboxyl-terminal fragment.
@en
prefLabel
γ-Secretase associated with li ...... β-carboxyl-terminal fragment.
@en
P2093
P2860
P356
P1476
γ-Secretase associated with li ...... β-carboxyl-terminal fragment.
@en
P2093
Hitomi Fujiwara
Maho Morishima-Kawashima
Mako Takami
Nobutaka Matsumura
Satoko Wada-Kakuda
Satoru Funamoto
Shinji Tagami
Yasuo Ihara
P2860
P304
P356
10.1074/JBC.M113.510131
P407
P577
2013-12-28T00:00:00Z