about
Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complexConstitutive phosphorylation of the Parkinson's disease associated alpha-synucleinPresenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptideEffect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.Laughter and humor as complementary and alternative medicines for dementia patients.Fluvoxamine alleviates ER stress via induction of Sigma-1 receptorDifferential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs.The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1Apolipoprotein E and central nervous system disorders: reviews of clinical findings.Presenilin 1 cleavage is a universal event in human organs.Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations.Identification and characterization of presenilin I-467, I-463 and I-374.Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.Abnormal gel-electrophoretic behavior of presenilin 1 and it's fragment.Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor.Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients.Altered localization of amyloid precursor protein under endoplasmic reticulum stress.Secretion of the Notch-1 Abeta-like peptide during Notch signaling.Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells.γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice.Absolute quantitation of low abundance plasma APL1β peptides at sub-fmol/mL Level by SRM/MRM without immunoaffinity enrichment.Involvement of endoplasmic reticulum stress in tauopathy.Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils.Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study.Association study of KIBRA gene with memory performance in a Japanese population.The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.Presenilin-1 exists in the axoplasm fraction in the brains of aged Down's syndrome subjects and non-demented individuals.TATA box-binding protein gene is associated with risk for schizophrenia, age at onset and prefrontal function.Glial tau-positive structures lack the sequence encoded by exon 3 of the tau protein gene.The AKT1 gene is associated with attention and brain morphology in schizophrenia.Relative ratio and level of amyloid-β 42 surrogate in cerebrospinal fluid of familial Alzheimer disease patients with presenilin 1 mutations.Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia.The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.FAD-linked presenilin-1 mutants impede translation regulation under ER stress.
P50
Q24303928-DEC4B2BE-5DD0-43CE-9912-9F69355E040CQ28141645-701748D6-8D01-45FF-BB6F-8A147558D6E6Q28201180-0121A5EE-6453-4A97-9F83-C7E0121A1D58Q33248032-01ADE3E6-EE86-4242-AB94-DCC8C6E896AEQ33611051-C87D0AA6-32B2-4297-8094-A8084D5A499AQ34007801-2B914AC0-1BD8-457B-872A-41325527B6DEQ34477370-A05B1C79-A866-475A-9E3E-31A5FFE370EAQ36042072-17F69395-FB54-400C-B431-F6049FB10525Q36421137-28D14474-9FBF-41C5-8943-3EB68EB780BCQ37812145-9919574E-A18D-4C48-AADD-A3B194D29E5DQ39320295-9C33A33B-F25C-43A2-BD0F-B41D483A0912Q39320300-3E154EE5-D7E5-4BB0-AD91-4FD75942FE5EQ39420719-9E440B99-4E7A-447B-877A-CE30F580FE04Q39517308-296C6078-1A78-4050-AEF5-80BDDC60EB27Q39611132-F4B84825-0A1C-4CBE-82AE-BAF9C8D12809Q39659066-DED37ED7-4967-4DED-9A3A-DE65717B8518Q39801938-FA9ED2B5-2E91-4055-A40E-B0ED3F0E1856Q39900200-4D893846-1CA6-4C06-B3E9-2CF32EEB509CQ40289222-BAEF2041-6833-49D0-A5CF-E89C5636C234Q40325565-B2535686-3FB3-458D-BD09-240FF71BD295Q40684851-E8DC35DA-E66A-4155-B0A5-C643057DFFA0Q40851871-2C8E6DAA-15B8-48AA-B97F-3F1C3C09B504Q41831750-D6B6DC73-656A-4A0B-AE43-5658D1B6C240Q43612913-188784D9-D453-46C6-AE32-1EF6A5099799Q44791563-3D567294-645A-44A7-8780-7D4693E289E6Q45793353-197ED18F-4A78-469F-B170-EC179E8E1D04Q45856241-FF736B00-3FAF-4303-B8B9-500587DBB5D0Q46112227-F405AB77-1C30-4D06-B7B7-89942644B4E3Q47385936-DB635F43-4112-45EE-B270-E8E7C27148B6Q47416513-4E3E44C5-69E6-45A9-B593-9D74157B2224Q48167504-BE7B201C-4B39-43B1-B18E-57AE04E4D80FQ48545410-7C56D577-635E-4AD9-A42E-74CBC6775AFEQ48761918-7D65F3F8-4EA3-4885-A5D0-1038254DF8E4Q48794168-3E60BD2D-9E42-4700-9868-97AFF28534C9Q48891851-5BCABC99-18AC-4C0C-94EF-28D0052895B7Q50779931-155F34E6-ECA2-45FD-928E-3BE04BC923ACQ51035733-74630B3C-33CE-4182-B3C5-E15F1E62ECC9Q51949330-E22901FD-FC8A-4D68-8B43-A3788AC8FE95Q53299554-9A8785BB-1372-4DFA-906F-AC409F760D58Q53353858-949DAEE0-9D44-41A0-B677-5F1DA0BEC265
P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Masayasu Okochi
@ast
Masayasu Okochi
@en
Masayasu Okochi
@es
Masayasu Okochi
@nl
Masayasu Okochi
@sl
type
label
Masayasu Okochi
@ast
Masayasu Okochi
@en
Masayasu Okochi
@es
Masayasu Okochi
@nl
Masayasu Okochi
@sl
prefLabel
Masayasu Okochi
@ast
Masayasu Okochi
@en
Masayasu Okochi
@es
Masayasu Okochi
@nl
Masayasu Okochi
@sl
P106
P1153
7003966935
P21
P31
P496
0000-0002-2318-7651
P569
2000-01-01T00:00:00Z