Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.
about
N-myristoyltransferase inhibitors as new leads to treat sleeping sicknessDissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methodsOne Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual ScreeningDevelopment and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductaseChemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosomeCell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma bruceiAllosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralogPyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream formsSynergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruziTrypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate SynthaseEvaluation of high efficiency gene knockout strategies for Trypanosoma cruziIdentification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China.Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in miceCross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.Target validation: linking target and chemical properties to desired product profileHomoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei.Interwoven biology of the tsetse holobiont.Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi, the Chagas disease pathogen.State of the art in African trypanosome drug discovery.Folate metabolic pathways in LeishmaniaDetermination of antiprotozoal drug mechanisms by metabolomics approaches.Drug discovery for neglected diseases: molecular target-based and phenotypic approaches.Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.Substrate channeling between the human dihydrofolate reductase and thymidylate synthase.Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines.Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major.Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.Genetically attenuated Trypanosoma cruzi parasites as a potential vaccination tool.A comparative study of methylglyoxal metabolism in trypanosomatids.Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei.Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid FolateomePharmacological Metabolomics in Trypanosomes
P2860
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P2860
Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Chemical and genetic validatio ...... arget in African trypanosomes.
@en
type
label
Chemical and genetic validatio ...... arget in African trypanosomes.
@en
prefLabel
Chemical and genetic validatio ...... arget in African trypanosomes.
@en
P2860
P1476
Chemical and genetic validatio ...... arget in African trypanosomes.
@en
P2093
Natasha Sienkiewicz
Szymon Jarosławski
P2860
P304
P356
10.1111/J.1365-2958.2008.06305.X
P407
P577
2008-07-01T00:00:00Z