Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. - Wikidata - awgldk - TriplyDB

Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.

Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.

http://www.wikidata.org/entity/Q41837475

about

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability Fbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human Tumorigenesis BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway FBXW7 expression is associated with prognosis and chemotherapeutic outcome in Chinese patients with gastric adenocarcinoma Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Roles of F-box proteins in cancer The landscape of somatic chromosomal copy number aberrations in GEM models of prostate carcinoma.Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator Oncogenic mutations in the FBXW7 gene of adult T-cell leukemia patients Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells.Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease.Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond.FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15.Runx3 in Immunity, Inflammation and Cancer.Genetic mutations in human rectal cancers detected by targeted sequencing.Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture.FBXL20 acts as an invasion inducer and mediates E-cadherin in colorectal adenocarcinoma.Ubiquitin ligases in oncogenic transformation and cancer therapy.Notch Signaling in Development, Tissue Homeostasis, and Disease.Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer.Role of Fbxw7 expression in hepatocellular carcinoma and adjacent non-tumor liver tissue.FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis.Knockdown of FBXO39 inhibits proliferation and promotes apoptosis of human osteosarcoma U-2OS cells.FBXW7: a critical tumor suppressor of human cancers

P2860

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P2860

Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.

http://www.wikidata.org/entity/Q41837475

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Fbw7 and p53 cooperatively sup ...... ly unstable intestinal cancer.

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type

label

Fbw7 and p53 cooperatively sup ...... ly unstable intestinal cancer.

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prefLabel

Fbw7 and p53 cooperatively sup ...... ly unstable intestinal cancer.

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Molecular and Cellular Biology

P1476

Fbw7 and p53 cooperatively sup ...... ly unstable intestinal cancer.

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P2093

Amanda Hagar

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Bruce E Clurman

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Jeffrey J Delrow

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Jessica Hespelt

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Jherek Swanger

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Jonathan E Grim

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Katherine A Guthrie

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Keiichi I Nakayama

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Sue E Knoblaugh

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Tom Small

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P2860

Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

A genetic model for colorectal tumorigenesis

The genomic landscapes of human breast and colorectal cancers

Genetic instabilities in human cancers

Tumor suppression by Ink4a-Arf: progress and puzzles

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse.

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.

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10.1128/MCB.00305-12

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11

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32

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