Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.
about
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stabilityFbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human TumorigenesisBCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal CancerDeregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathwayFBXW7 expression is associated with prognosis and chemotherapeutic outcome in Chinese patients with gastric adenocarcinomaChromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulationOncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Roles of F-box proteins in cancerThe landscape of somatic chromosomal copy number aberrations in GEM models of prostate carcinoma.Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with MediatorOncogenic mutations in the FBXW7 gene of adult T-cell leukemia patientsDiverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap AccumulationFBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumorsRole of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells.Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease.Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond.FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15.Runx3 in Immunity, Inflammation and Cancer.Genetic mutations in human rectal cancers detected by targeted sequencing.Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture.FBXL20 acts as an invasion inducer and mediates E-cadherin in colorectal adenocarcinoma.Ubiquitin ligases in oncogenic transformation and cancer therapy.Notch Signaling in Development, Tissue Homeostasis, and Disease.Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer.Role of Fbxw7 expression in hepatocellular carcinoma and adjacent non-tumor liver tissue.FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis.Knockdown of FBXO39 inhibits proliferation and promotes apoptosis of human osteosarcoma U-2OS cells.FBXW7: a critical tumor suppressor of human cancers
P2860
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P2860
Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Fbw7 and p53 cooperatively sup ...... ly unstable intestinal cancer.
@en
type
label
Fbw7 and p53 cooperatively sup ...... ly unstable intestinal cancer.
@en
prefLabel
Fbw7 and p53 cooperatively sup ...... ly unstable intestinal cancer.
@en
P2093
P2860
P356
P1476
Fbw7 and p53 cooperatively sup ...... ly unstable intestinal cancer.
@en
P2093
Amanda Hagar
Bruce E Clurman
Jeffrey J Delrow
Jessica Hespelt
Jherek Swanger
Jonathan E Grim
Katherine A Guthrie
Keiichi I Nakayama
Sue E Knoblaugh
P2860
P304
P356
10.1128/MCB.00305-12
P407
P577
2012-04-02T00:00:00Z