Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. - Wikidata - awgldk - TriplyDB

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.

http://www.wikidata.org/entity/Q34324063

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Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells PALB2 is an integral component of the BRCA complex required for homologous recombination repair N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks MERIT40 facilitates BRCA1 localization and DNA damage repair NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control CCDC98 targets BRCA1 to DNA damage sites Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks Human CtIP promotes DNA end resection The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response BRCA mutations and childhood cancer Fine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at work BRCA1, a 'complex' protein involved in the maintenance of genomic stability Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks Homologs of breast cancer genes in plants The MRN-CtIP pathway is required for metaphase chromosome alignment.FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner.Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions.FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants.Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80 The UPS: a promising target for breast cancer treatment.BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control.Molecular markers of paragangliomas/pheochromocytomas Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.Charting the landscape of tandem BRCT domain-mediated protein interactions.BARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility.

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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.

http://www.wikidata.org/entity/Q34324063

description

2006 nî lūn-bûn

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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2006 թվականի հունվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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Multifactorial contributions t ...... A1/BARD1-containing complexes.

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Multifactorial contributions t ...... A1/BARD1-containing complexes.

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Multifactorial contributions t ...... A1/BARD1-containing complexes.

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Multifactorial contributions t ...... A1/BARD1-containing complexes.

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Multifactorial contributions t ...... A1/BARD1-containing complexes.

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Multifactorial contributions t ...... A1/BARD1-containing complexes.

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Multifactorial contributions t ...... A1/BARD1-containing complexes.

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Multifactorial contributions t ...... A1/BARD1-containing complexes.

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Genes & Development

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Multifactorial contributions t ...... A1/BARD1-containing complexes.

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Bijan Sobhian

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David M Livingston

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Roger A Greenberg

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Shailja Pathania

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Sharon B Cantor

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Yoshihiro Nakatani

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P2860

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

Dominant Negative ATM Mutations in Breast Cancer Families

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

The BRCT domain is a phospho-protein binding domain

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

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34-46

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10.1101/GAD.1381306

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1

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20

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2006-01-01T00:00:00Z

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7380645

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16391231

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P921

BRCA1-C complex

BRCA1-B complex

P932

1356099

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