Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase
about
P110delta, a novel phosphoinositide 3-kinase in leukocytesAutophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivoInvolvement of Janus kinases in the insulin signaling pathwayInsulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathwaysHigh-fat diet alters PP2A, TC10, and CIP4 expression in visceral adipose tissue of ratsSurfing the insulin signaling webIdentification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibitionOncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinaseProtein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survivalOncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.Turning down insulin signaling.Fragments of ATM which have dominant-negative or complementing activity.Human adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signaling.Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36.Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.ATM heterozygosity and breast cancer: screening of 37 breast cancer patients for ATM mutations using a non-isotopic RNase cleavage-based assay.Anti-hypoxic effect of ginsenoside Rbl on neonatal rat cardiomyocytes is mediated through the specific activation of glucose transporter-4 ex vivo.Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase.Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110alpha and p110beta catalytic subunits of class-Ia phosphoinositide 3-kinases.Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells.Ataxia-telangiectasia and the ATM gene: linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints.Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmannin.Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance.Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinaseCross-talk between the platelet-derived growth factor and the insulin signaling pathways in 3T3-L1 adipocytes.IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress.Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells.Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport.Identification of enhanced serine kinase activity in insulin resistance.Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells.Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling.Phosphatidylinositol 3'-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase.In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation.Enhancement of erbB2 and erbB3 expression during oral oncogenesis in diabetic rats.PTEN Inhibits High Glucose-Induced Phenotypic Transition in Podocytes.
P2860
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P2860
Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Insulin receptor substrate 1 i ...... phosphatidylinositol 3-kinase
@en
type
label
Insulin receptor substrate 1 i ...... phosphatidylinositol 3-kinase
@en
prefLabel
Insulin receptor substrate 1 i ...... phosphatidylinositol 3-kinase
@en
P2093
P2860
P356
P1433
P1476
Insulin receptor substrate 1 i ...... phosphatidylinositol 3-kinase
@en
P2093
Grémeaux T
Le Marchand-Brustel Y
Van Obberghen E
P2860
P356
10.1042/BJ3040017
P407
P478
304 ( Pt 1)
P577
1994-11-01T00:00:00Z