Mechanism of catabolism of aggrecan by articular cartilage.
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Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecanAge-related changes in the content of the C-terminal region of aggrecan in human articular cartilageAggrecanases and cartilage matrix degradationAggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.Expression and activity of ADAMTS-5 in synovium.The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage.Articular cartilage and osteoarthrosis. The role of molecular markers to monitor breakdown, repair and disease.Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine.Mechanisms involved in enhancement of the expression and function of aggrecanases by hyaluronan oligosaccharidesBlocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repairAn enzyme-sensitive PEG hydrogel based on aggrecan catabolism for cartilage tissue engineeringContaminants in commercial preparations of 'purified' small leucine-rich proteoglycans may distort mechanistic studies.LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilageA Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active OligomersMembrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis.The utility of ionotropic glutamate receptor antagonists in the treatment of nociception induced by epidural glutamate infusion in ratsAggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 bCurrent serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix.Increased expression of CD44 in bovine articular chondrocytes by catabolic cellular mediators.N- and O-linked keratan sulfate on the hyaluronan binding region of aggrecan from mature and immature bovine cartilage.Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity.The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells.Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes."Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay.Proteolytic mechanisms of cartilage breakdown: a target for arthritis therapy?Inhibitors of collagenase but not of gelatinase reduce cartilage explant proteoglycan breakdown despite only low levels of matrix metalloproteinase activity.Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain.Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1beta-stimulated catabolism.Proteoglycans isolated from dissociative extracts of differently aged human articular cartilage: characterization of naturally occurring hyaluronan-binding fragments of aggrecanProteoglycans and catabolic products of proteoglycans present in ligament.Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids.Increased vulnerability of postarthritic cartilage to a second arthritic insult: accelerated MMP activity in a flare up of arthritis.
P2860
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P2860
Mechanism of catabolism of aggrecan by articular cartilage.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Mechanism of catabolism of aggrecan by articular cartilage.
@en
type
label
Mechanism of catabolism of aggrecan by articular cartilage.
@en
prefLabel
Mechanism of catabolism of aggrecan by articular cartilage.
@en
P2093
P1476
Mechanism of catabolism of aggrecan by articular cartilage.
@en
P2093
P304
P356
10.1016/0003-9861(92)90144-L
P407
P577
1992-04-01T00:00:00Z