Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?
about
Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives.hERG-related drug toxicity and models for predicting hERG liability and QT prolongation.Ion channel trafficking: a new therapeutic horizon for atrial fibrillationConcise review: Human pluripotent stem cell-based models for cardiac and hepatic toxicity assessment.Improved functional expression of human cardiac kv1.5 channels and trafficking-defective mutants by low temperature treatmentAcute cardiotoxicity evaluation of the marine biotoxins OA, DTX-1 and YTXMolecular determinants of pentamidine-induced hERG trafficking inhibition.Long-term treatment with ivabradine in post-myocardial infarcted rats counteracts f-channel overexpression.Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cellsAn introduction to QT interval prolongation and non-clinical approaches to assessing and reducing riskForward trafficking of ion channels: what the clinician needs to know.Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue.Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5.Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.Finding inward rectifier channel inhibitors: why and how?Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine.Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment.The rescuable function and mechanism of resveratrol on As₂O₃-induced hERG K⁺ channel deficiency.hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine.Comprehensive review of cardiovascular toxicity of drugs and related agents.
P2860
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P2860
Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?
@en
type
label
Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?
@en
prefLabel
Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?
@en
P2860
P356
P1476
Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?
@en
P2860
P304
P356
10.1038/SJ.BJP.0707618
P407
P577
2007-12-03T00:00:00Z