Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation
about
LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stressLRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's DiseaseParkinson's disease: insights from pathways.Towards human central nervous system in vitro models for preclinical research: strategies for 3D neural cell culture.The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalitiesLRRK2: an éminence grise of Wnt-mediated neurogenesis?Modeling Parkinson's disease using induced pluripotent stem cells.I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.Adeno-associated virus type 2 vector-mediated glial cell line-derived neurotrophic factor gene transfer induces neuroprotection and neuroregeneration in a ubiquitin-proteasome system impairment animal model of Parkinson's disease.Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival.
P2860
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P2860
Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Emerging role of LRRK2 in huma ...... , survival and differentiation
@en
type
label
Emerging role of LRRK2 in huma ...... , survival and differentiation
@en
prefLabel
Emerging role of LRRK2 in huma ...... , survival and differentiation
@en
P2093
P2860
P356
P1476
Emerging role of LRRK2 in huma ...... , survival and differentiation
@en
P2093
Alexander Storch
Anne K Meyer
Javorina Milosevic
Johannes Schwarz
Sigrid C Schwarz
Vera Ogunlade
P2860
P2888
P356
10.1186/1750-1326-4-25
P577
2009-06-15T00:00:00Z
P5875
P6179
1043266472