Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation.
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DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formationChromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancerDNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cellsDNA ligase III: a spotty presence in eukaryotes, but an essential function where testedTargeting abnormal DNA repair in therapy-resistant breast cancersTelomere dysfunction and chromosome instabilityHomologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian CancerThe role of RecQ helicases in non-homologous end-joiningReplication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrityRepair of strand breaks by homologous recombinationThe convergence of DNA damage checkpoint pathways and androgen receptor signaling in prostate cancerThe DNA Damage Response: Making It Safe to Play with KnivesBalancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Noncanonical views of homology-directed DNA repairSnaps and mends: DNA breaks and chromosomal translocationsMicrohomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?The response to and repair of RAG-mediated DNA double-strand breaksHomology and enzymatic requirements of microhomology-dependent alternative end joiningMitotic homologous recombination maintains genomic stability and suppresses tumorigenesisATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaksMechanism of suppression of chromosomal instability by DNA polymerase POLQMammalian polymerase θ promotes alternative NHEJ and suppresses recombinationMechanisms for Structural Variation in the Human GenomeA noncatalytic function of the ligation complex during nonhomologous end joining.Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.DNA double-strand break repair in Penaeus monodon is predominantly dependent on homologous recombination.Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors.Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.Efficient Recreation of t(11;22) EWSR1-FLI1+ in Human Stem Cells Using CRISPR/Cas9.Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining.Drugging the Cancers Addicted to DNA Repair.Origin of chromosomal translocations in lymphoid cancer.Single molecule PCR reveals similar patterns of non-homologous DSB repair in tobacco and Arabidopsis.Removal of shelterin reveals the telomere end-protection problem.Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cellsDevelopment of synthetic lethality anticancer therapeutics.DNA ligases as therapeutic targetsDe novo CNV formation in mouse embryonic stem cells occurs in the absence of Xrcc4-dependent nonhomologous end joining.
P2860
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P2860
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Alternative end-joining is sup ...... somal translocation formation.
@en
type
label
Alternative end-joining is sup ...... somal translocation formation.
@en
prefLabel
Alternative end-joining is sup ...... somal translocation formation.
@en
P2860
P356
P1476
Alternative end-joining is sup ...... somal translocation formation.
@en
P2093
Deniz Simsek
Maria Jasin
P2860
P2888
P304
P356
10.1038/NSMB.1773
P577
2010-03-07T00:00:00Z
P5875
P6179
1033094941