Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition.
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Key Targets for Multi-Target Ligands Designed to Combat NeurodegenerationCytochrome P450-mediated drug metabolism in the brainTargeting therapeutics across the blood brain barrier (BBB), prerequisite towards thrombolytic therapy for cerebrovascular disorders-an overview and advancementsPCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanismsEthanol self-administration and nicotine treatment increase brain levels of CYP2D in African green monkeys.A brain-specific cytochrome P450 responsible for the majority of deltamethrin resistance in the QTC279 strain of Tribolium castaneum.Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function.Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic.Monocrotophos induces the expression and activity of xenobiotic metabolizing enzymes in pre-sensitized cultured human brain cells.Cytochrome P450 enzymes in the brain: emerging evidence of biological significanceTranscriptional Changes in nAChRs, Interactive Proteins and P450s in Locusta migratoria manilensis (Orthoptera: Acrididae) CNS in Response to High and Low Oral Doses of Imidacloprid.First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo.CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells.A role for CYP in the drug-hormone crosstalk of the brain.ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders.Modeling bioavailability to organs protected by biological barriers.Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs.Effect of Brain CYP2B Inhibition on Brain Nicotine Levels and Nicotine Self-Administration.Drug metabolism within the brain changes drug response: selective manipulation of brain CYP2B alters propofol effects.CYP2E1 regulates the development of radiation-induced pulmonary fibrosis via ER stress- and ROS-dependent mechanisms.Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.Regulation of cerebral CYP2D alters tramadol metabolism in the brain: interactions of tramadol with propranolol and nicotine.
P2860
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P2860
Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Brain drug-metabolizing cytoch ...... anism-based enzyme inhibition.
@en
type
label
Brain drug-metabolizing cytoch ...... anism-based enzyme inhibition.
@en
prefLabel
Brain drug-metabolizing cytoch ...... anism-based enzyme inhibition.
@en
P2860
P356
P1476
Brain drug-metabolizing cytoch ...... hanism-based enzyme inhibition
@en
P2093
Sharon Miksys
P2860
P2888
P304
P356
10.1038/NPP.2008.110
P407
P577
2008-07-30T00:00:00Z
P5875
P6179
1023437696