Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin. - Wikidata - awgldk - TriplyDB

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin.

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin.

http://www.wikidata.org/entity/Q41882101

about

Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions Food for thought: the role of appetitive peptides in age-related cognitive decline The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice.Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease Metabolic, inflammatory, and microvascular determinants of white matter disease and cognitive decline.Mitochondria in Alzheimer's Disease and Diabetes-Associated Neurodegeneration: License to Heal!Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation Role of insulin signaling impairment, adiponectin and dyslipidemia in peripheral and central neuropathy in mice Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice.Diabetes induces changes in ILK, PINCH and components of related pathways in the spinal cord of rats.Insulin Attenuates Beta-Amyloid-Associated Insulin/Akt/EAAT Signaling Perturbations in Human Astrocytes Brain aging and AD-like pathology in streptozotocin-induced diabetic rats.GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.Linking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediators.Late onset Alzheimer's disease in older people.Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain.Temporal dystrophic remodeling within the intrinsic cardiac nervous system of the streptozotocin-induced diabetic rat model Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis.Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats.The effect of Chinese Jinzhida recipe on the hippocampus in a rat model of diabetes-associated cognitive decline A common pathogenic mechanism linking type-2 diabetes and Alzheimer's disease: evidence from animal models.Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models.Treadmill exercise decreases incidence of Alzheimer's disease by suppressing glycogen synthase kinase-3β expression in streptozotocin-induced diabetic rats.Consequences of Aberrant Insulin Regulation in the Brain: Can Treating Diabetes be Effective for Alzheimer's Disease.Cognitive dysfunction associated with diabetic ketoacidosis in rats Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes Activation of the insulin-signaling pathway in sciatic nerve and hippocampus of type 1 diabetic rats.Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice.Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice.Crocin improved learning and memory impairments in streptozotocin-induced diabetic rats.Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged A Role for Insulin in Diabetic Neuropathy.

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Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin.

http://www.wikidata.org/entity/Q41882101

description

2008 nî lūn-bûn

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Defective insulin signaling pa ...... ase and correction by insulin.

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Defective insulin signaling pa ...... ase and correction by insulin.

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Defective insulin signaling pa ...... ase and correction by insulin.

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Journal of Neuroscience Research

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Defective insulin signaling pa ...... ase and correction by insulin.

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P2093

C A Lee

http://www.w3.org/2001/XMLSchema#string

C G Jolivalt

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E Masliah

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J L Smith

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K K Beiswenger

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M A Torrance

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M Orlov

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P2860

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

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10.1002/JNR.21787

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15

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86

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18627032

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Alzheimer's disease

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4937800

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