Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4
about
AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesisSlp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapseRab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cellsPrimary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification CommitteeNew Insights into How Trafficking Regulates T Cell Receptor SignalingComparative Anatomy of Phagocytic and Immunological SynapsesLysosome-Related Effector Vesicles in T Lymphocytes and NK CellsCell biological steps and checkpoints in accessing NK cell cytotoxicityRegulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectorsMunc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responsesVisualization of cytolytic T cell differentiation and granule exocytosis with T cells from mice expressing active fluorescent granzyme BDistinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cellsDiacylglycerol Kinases in T Cell Tolerance and Effector FunctionMelanosome transfer: it is best to give and receiveTwo modes of lytic granule fusion during degranulation by natural killer cellsFas death receptor enhances endocytic membrane traffic converging into the Golgi regionMyosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse.Imaging effector functions of human cytotoxic CD4+ T cells specific for Plasmodium falciparum circumsporozoite protein.NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophagesImaging of lytic granule exocytosis in CD8+ cytotoxic T lymphocytes reveals a modified form of full fusion.Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse.Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.Munc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles.EBAG9 tempers lymphocyte killing activity.Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders.Loss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patientsCell biology and physiology of the uroepithelium.Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome PatientsTranscriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.Rab27a is required for human cytomegalovirus assembly.Navigating barriers: the challenge of directed secretion at the natural killer cell lytic immunological synapse.BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cellsStepwise maturation of lytic granules during differentiation and activation of human CD8+ T lymphocytes.Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis.Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms.The complex ultrastructure of the endolysosomal system.Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophilsBlockade of Kv1.3 potassium channels inhibits differentiation and granzyme B secretion of human CD8+ T effector memory lymphocytes.Perforin deficiency and susceptibility to cancer.Variations of the UNC13D gene in patients with autoimmune lymphoproliferative syndrome.
P2860
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P2860
Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@ast
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@en
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@en-gb
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@nl
type
label
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@ast
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@en
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@en-gb
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@nl
prefLabel
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@ast
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@en
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@en-gb
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@nl
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
Secretory cytotoxic granule ma ...... the effector protein hMunc13-4
@en
P2093
Chen-Hsuan Ho
Jérôme Feldmann
Maryse Romao
Mickaël M Ménager
Mériem Garfa
P2860
P304
P3181
P356
10.1038/NI1431
P407
P577
2007-03-01T00:00:00Z