about
Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlaysThermodynamic optimisation in drug discovery: a case study using carbonic anhydrase inhibitorsTranscriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic OpportunitiesApplications of chemogenomic library screening in drug discoveryPhysicochemical drug properties associated with in vivo toxicological outcomes: a review.Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action.Target validation using chemical probes.Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in miceClick chemistry patents and their impact on drug discovery and chemical biology.A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.Cell permeable affinity- and activity-based probes.A flow cytometry-based screen identifies MBNL1 modulators that rescue splicing defects in myotonic dystrophy type I.Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium.Squaramides: physical properties, synthesis and applications.Dual-pharmacology muscarinic antagonist and β₂ agonist molecules for the treatment of chronic obstructive pulmonary disease.Molecular scaffolds using multiple orthogonal conjugations: applications in chemical biology and drug discovery.Chemistry and biology of biomolecule nitration.Medicinal chemistry of glucagon-like peptide receptor agonists.Understanding and applying tyrosine biochemical diversity.TAK1 selective inhibition: state of the art and future opportunities.Recent advances in the molecular design of synthetic vaccines.Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.Modern advances in heterocyclic chemistry in drug discovery.Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.Clinical chemoproteomics-Opportunities and obstacles.Sulfonyl fluorides as privileged warheads in chemical biologyUptake, efficacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense.Optimization of 5-aryloxyimidazole non-nucleoside reverse transcriptase inhibitors.Synthetic phosphorylation of p38α recapitulates protein kinase activityBinding site elucidation and structure guided design of macrocyclic IL-17A antagonists.A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones.In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels.In-cell click labelling of small molecules to determine subcellular localisation.Pyrazole NNRTIs 3: optimisation of physicochemical properties.Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: implications for an alternative enediyne therapeutic mechanism.Antibody catalysis of the oxidation of water.TAK1 inhibition in the DFG-out conformation.Relaying stereochemistry through aromatic ureas: 1,9 and 1,15 remote stereocontrol.Selectivity Determination of a Small Molecule Chemical Probe Using Protein Microarray and Affinity Capture Techniques.Helix persistence and breakdown in oligoureas of metaphenylenediamine: apparent diastereotopicity as a spectroscopic marker of helix length in solution.
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Lyn H Jones
@es
Lyn H. Jones
@en
Lyn H. Jones
@sl
لين إتش. جونز
@ar
type
label
Lyn H Jones
@es
Lyn H. Jones
@en
Lyn H. Jones
@sl
لين إتش. جونز
@ar
prefLabel
Lyn H Jones
@es
Lyn H. Jones
@en
Lyn H. Jones
@sl
لين إتش. جونز
@ar
P106
P1153
7403623438
P21
P2798
P31
P3835
lyn-jones2
P496
0000-0002-8388-5865
P569
2000-01-01T00:00:00Z