Src kinase activation: A switched electrostatic network.
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Inositol phosphate-induced stabilization of inositol 1,3,4,5,6-pentakisphosphate 2-kinase and its role in substrate specificityMutations in the catalytic loop HRD motif alter the activity and function of Drosophila Src64Hotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivityThe Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape.Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.Locking the active conformation of c-Src kinase through the phosphorylation of the activation loopHierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectoriesAn electrostatic network and long-range regulation of Src kinasesConformational stability of inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) dictates its substrate selectivity.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.Recruitment of rare 3-grams at functional sites: is this a mechanism for increasing enzyme specificity?Src kinase conformational activation: thermodynamics, pathways, and mechanisms.Sequence and structure signatures of cancer mutation hotspots in protein kinasesDynamic, structural and thermodynamic basis of insulin-like growth factor 1 kinase allostery mediated by activation loop phosphorylation.Large conformational changes in proteins: signaling and other functions.Maximum Flux Transition Paths of Conformational ChangeAnalysis of Somatic Mutations in Cancer: Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases.Activation pathway of Src kinase reveals intermediate states as targets for drug designConformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90.Expression and purification of Src-family kinases for solution NMR studies.Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing.αC helix as a switch in the conformational transition of Src/CDK-like kinase domains.Transitions to catalytically inactive conformations in EGFR kinaseMultiple steps to activate FAK's kinase domain: adaptation to confined environments?A Comparison of Three Perturbation Molecular Dynamics Methods for Modeling Conformational Transitions.Flexibility and charge asymmetry in the activation loop of Src tyrosine kinasesRoles of phosphate recognition in inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) substrate binding and activation.Computational study of the W260A activating mutant of Src tyrosine kinase.Evaluating the dynamics and electrostatic interactions of folded proteins in implicit solvents.Molecular dynamics simulations show that conformational selection governs the binding preferences of imatinib for several tyrosine kinases.Unrestrained computation of free energy along a path.Hsp90 dependence of a kinase is determined by its conformational landscapeMolecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinasesAtomistic view of the conformational activation of Src kinase using the string method with swarms-of-trajectories.A switch in nucleotide affinity governs activation of the Src and Tec family kinases.Piezoelectric allostery of protein.Hypoxia and Selective Autophagy in Cancer Development and Therapy
P2860
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P2860
Src kinase activation: A switched electrostatic network.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Src kinase activation: A switched electrostatic network.
@en
type
label
Src kinase activation: A switched electrostatic network.
@en
prefLabel
Src kinase activation: A switched electrostatic network.
@en
P2860
P356
P1433
P1476
Src kinase activation: A switched electrostatic network.
@en
P2093
Carol Beth Post
Elif Ozkirimli
P2860
P304
P356
10.1110/PS.051999206
P577
2006-04-05T00:00:00Z