Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.
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A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of ChloroquineOn the molecular mechanism of chloroquine's antimalarial actionThe relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloidsPolymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquineTargeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial ResistanceGenome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt geneChloroquine clinical failures in P. falciparum malaria are associated with mutant Pfmdr-1, not Pfcrt in MadagascarOn the mechanism of chloroquine resistance in Plasmodium falciparumInvestigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT)A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuoleChloroquine transport via the malaria parasite's chloroquine resistance transporterHigh-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinationsMutations in the pfmdr1, dhfr and dhps genes of Plasmodium falciparum are associated with in-vivo drug resistance in West Papua, Indonesia.Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 geneParallel synthesis and antimalarial screening of a 4-aminoquinoline library.Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based DrugsA Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug PiperaquineDiverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporterCloning by gene amplification of two loci conferring multiple drug resistance in SaccharomycesSelection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum.Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum.Assessment of three in vitro tests and an in vivo test for chloroquine resistance in Plasmodium falciparum clinical isolates.Reversal agent and linker variants of reversed chloroquines: activities against Plasmodium falciparum.Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae.Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds.PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.Transporters involved in resistance to antimalarial drugs.Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.Membrane transport in the malaria-infected erythrocyte.Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase.Probing the chloroquine resistance locus of Plasmodium falciparum with a novel class of multidentate metal(III) coordination complexes.Biochemical and molecular mechanisms of drug resistance in parasites.Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT.4-aminoquinolines active against chloroquine-resistant Plasmodium falciparum: basis of antiparasite activity and quantitative structure-activity relationship analysesIn vivo and in vitro antimalarial properties of azithromycin-chloroquine combinations that include the resistance reversal agent amlodipinePfCRT-mediated drug transport in malarial parasites.Specific inhibition of the plasmodial surface anion channel by dantroleneThe multixenobiotic resistance mechanism in aquatic organisms.Potentiation of chloroquine activity against Plasmodium falciparum by the peroxidase-hydrogen peroxide system.Antimalarial agents: mechanism of chloroquine resistance
P2860
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P2860
Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.
@en
type
label
Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.
@en
prefLabel
Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.
@en
P2093
P356
P1433
P1476
Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance
@en
P2093
A M Oduola
D J Krogstad
I Y Gluzman
P H Schlesinger
S K Martin
W K Milhous
P304
P356
10.1126/SCIENCE.3317830
P407
P577
1987-11-01T00:00:00Z