about
Regulation of BRCA1 expression and its relationship to sporadic breast cancerExpression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational controlGene Expression Profiling of Primary Cutaneous Melanoma and Clinical OutcomeLack of spartin protein in Troyer syndrome: a loss-of-function disease mechanism?Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells.NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexesDo VHL and HIF-1 mirror p53 and Mdm-2? Degradation-transactivation loops of oncoproteins and tumor suppressors.Proteasomal inhibition enhances glucocorticoid receptor transactivation and alters its subnuclear trafficking.Breast cancer 1 (BRCA1)-deficient embryos develop normally but are more susceptible to ethanol-initiated DNA damage and embryopathies.BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells.Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines.Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis.Gene expression profiling and clinical outcome in melanoma: in search of novel prognostic factors.A unique carboxyl-terminal insert domain in the hematopoietic-specific, GTPase-deficient Rho GTPase RhoH regulates post-translational processing.Nuclear localization of catalytically active MMP-2 in endothelial cells and neurons.A transcriptionally inactive E2F-1 targets the MDM family of proteins for proteolytic degradation.Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression.Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block.Fanconi anemia D2 protein is an apoptotic target mediated by caspases.Repression of BRCA1 through a feedback loop involving p53.The C-terminal proteolytic fragment of the breast cancer susceptibility type 1 protein (BRCA1) is degraded by the N-end rule pathway.Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinomas.An adenoviral vector containing an arg-gly-asp (RGD) motif in the fiber knob enhances protein product levels from transgenes refractory to expression.Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation.Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis.NF-κB inhibition by dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma by blocking DNA double-strand break repair.
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Regulation of BRCA1 by protein degradation.
@en
type
label
Regulation of BRCA1 by protein degradation.
@en
prefLabel
Regulation of BRCA1 by protein degradation.
@en
P2093
P2860
P356
P1433
P1476
Regulation of BRCA1 by protein degradation.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1203068
P407
P577
1999-11-01T00:00:00Z
P5875
P6179
1041968762