An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials.
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The therapeutic potential of metal-based antimalarial agents: implications for the mechanism of action8-Aminoquinolines active against blood stage Plasmodium falciparum in vitro inhibit hematin polymerizationAntimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasitesImplications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and ArtemisininMutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistanceHematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores.Resonance Raman spectroscopy in malaria research.2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.In vitro activities of benflumetol against 158 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs.Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds.The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex.Plasmodium chloroquine resistance and the search for a replacement antimalarial drug.1,2-disubstituted ferrocenyl carbohydrate chloroquine conjugates as potential antimalarial agents.The concept of privileged structures in rational drug design: focus on acridine and quinoline scaffolds in neurodegenerative and protozoan diseases.Chloroquine resistance in the malarial parasite, Plasmodium falciparum.2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization.Chloroquine sensitivity: diminished prevalence of chloroquine-resistant gene marker pfcrt-76 13 years after cessation of chloroquine use in Msambweni, KenyaAntischistosomal activities of mefloquine-related arylmethanols.Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.Review of pyronaridine anti-malarial properties and product characteristics.A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum.Inhibitory effects of pepstatin A and mefloquine on the growth of Babesia parasitesInsights into the role of heme in the mechanism of action of antimalarials.The single crystal X-ray structure of β-hematin DMSO solvate grown in the presence of chloroquine, a β-hematin growth-rate inhibitorSequence analysis of pfcrt and pfmdr1 genes and its association with chloroquine resistance in Southeast Indian Plasmodium falciparum isolates.Prospects for the treatment of drug-resistant malaria parasites.1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agentsA physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs.Synthesis and antimalarial activities of cyclen 4-aminoquinoline analogs.Antimalarial drugs and heme in detergent micelles: An NMR study.Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malariaCytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis.Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model.Recent advances in the discovery of haem-targeting drugs for malaria and schistosomiasis.Herbicidal properties of antimalarial drugs.Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds.Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase.Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni.Plasma metabolomics reveals membrane lipids, aspartate/asparagine and nucleotide metabolism pathway differences associated with chloroquine resistance in Plasmodium vivax malariaCentral role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols.
P2860
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P2860
An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
An assessment of drug-haematin ...... on by quinoline antimalarials.
@en
type
label
An assessment of drug-haematin ...... on by quinoline antimalarials.
@en
prefLabel
An assessment of drug-haematin ...... on by quinoline antimalarials.
@en
P2093
P1476
An assessment of drug-haematin ...... on by quinoline antimalarials.
@en
P2093
P304
P356
10.1016/S0006-2952(97)00510-8
P407
P577
1998-03-01T00:00:00Z