The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors.
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Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterasesPhosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ currentMolecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitorThe human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipramSerotonin-elicited inhibition of Cl(-) secretion in the rabbit conjunctival epithelium.Progesterone treatment abolishes exogenously expressed ionic currents in Xenopus oocytes.Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.beta-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids.Sarcoplasmic reticulum-associated cyclic adenosine 5'-monophosphate phosphodiesterase activity in normal and failing human hearts.Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A.Myocardial phosphodiesterases and regulation of cardiac contractility in health and cardiac disease.Further analysis of the mechanisms underlying the tracheal relaxant action of SCA40.S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness.PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationEffects of phosphodiesterase inhibitors on human lung mast cell and basophil function.Characterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitorsHesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.Compartmentation of cAMP signaling in cardiac myocytes: a computational study.A comparison of vasodilator activity of agents activating cyclic nucleotides with those inhibiting their metabolism in rabbit isolated ear arteryHesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced AnesthesiaAssessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells.Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: biochemical and pharmacological analysis using selective inhibitors.Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchusInhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors.Endothelium-dependent and independent relaxation of the rat aorta by cyclic nucleotide phosphodiesterase inhibitors.Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle toneComputational biology in the study of cardiac ion channels and cell electrophysiology.Pharmacology of second messengers: a critical appraisal.A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation.Pharmacological mechanisms contributing to the clinical efficacy of levosimendan.Hesperidin-3'-o-methylether is more potent than hesperidin in phosphodiesterase inhibition and suppression of ovalbumin-induced airway hyperresponsiveness.Incomplete reversal of beta-adrenoceptor desensitization in human and guinea-pig cardiomyocytes by cyclic nucleotide phosphodiesterase inhibitorsCellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells.Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signalingIBMX-elicited inhibition of water permeability in the isolated rabbit conjunctival epithelium.BK channel-mediated relaxation of urinary bladder smooth muscle: a novel paradigm for phosphodiesterase type 4 regulation of bladder function.Phosphodiesterase inhibition by new cardiotonic agents: mechanism of action and possible clinical relevance in the therapy of congestive heart failure.Cyclic AMP signaling functions as a bimodal switch in sympathoadrenal cell development in cultured primary neural crest cells.Histochemistry of nucleotidyl cyclases and cyclic nucleotide phosphodiesterases.
P2860
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P2860
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
The identification of a new cy ...... phosphodiesterase inhibitors.
@en
type
label
The identification of a new cy ...... phosphodiesterase inhibitors.
@en
prefLabel
The identification of a new cy ...... phosphodiesterase inhibitors.
@en
P2093
P2860
P356
P1433
P1476
The identification of a new cy ...... phosphodiesterase inhibitors.
@en
P2093
P2860
P304
P356
10.1042/BJ2410535
P407
P577
1987-01-01T00:00:00Z