Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness. - Wikidata - awgldk - TriplyDB

Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness.

Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness.

http://www.wikidata.org/entity/Q41991320

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Optogenetics for neurodegenerative diseases.Multiple Independent Oscillatory Networks in the Degenerating Retina Emerging gene therapies for retinal degenerations Optogenetic approaches to retinal prosthesis AAV-mediated gene therapy in mouse models of recessive retinal degeneration Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity.Pulse trains to percepts: the challenge of creating a perceptually intelligible world with sight recovery technologies Biophysical Properties of Optogenetic Tools and Their Application for Vision Restoration Approaches Therapeutic potential of optogenetic neuromodulation Review: the history and role of naturally occurring mouse models with Pde6b mutations Development and utility of an internal threshold control (ITC) real-time PCR assay for exogenous DNA detection Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells Restoration of the majority of the visual spectrum by using modified Volvox channelrhodopsin-1.Maintaining ocular safety with light exposure, focusing on devices for optogenetic stimulation.rAAV-mediated subcellular targeting of optogenetic tools in retinal ganglion cells in vivo Optogenetics.Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration Optogenetic therapy for retinitis pigmentosa.Intrinsic bursting of AII amacrine cells underlies oscillations in the rd1 mouse retina Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter.PCR-based detection of gene transfer vectors: application to gene doping surveillance.A profile of transcriptomic changes in the rd10 mouse model of retinitis pigmentosa.Vector platforms for gene therapy of inherited retinopathies.Assessment of tropism and effectiveness of new primate-derived hybrid recombinant AAV serotypes in the mouse and primate retina Targeting channelrhodopsin-2 to ON-bipolar cells with vitreally administered AAV Restores ON and OFF visual responses in blind mice Optogenetics for retinal disorders LiGluR restores visual responses in rodent models of inherited blindness.Focal damage to macaque photoreceptors produces persistent visual loss.Optical control after transfection of channelrhodopsin-2 recombinant adenovirus in visual cortical cells ChR2 mutants at L132 and T159 with improved operational light sensitivity for vision restoration Principles of designing interpretable optogenetic behavior experiments.Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats Retinoid receptors trigger neuritogenesis in retinal degenerations Diversity of Chlamydomonas channelrhodopsins.Broad-Band Activatable White-Opsin Frequency and amplitude modulation have different effects on the percepts elicited by retinal stimulation.Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration Mutations in RD3 are associated with an extremely rare and severe form of early onset retinal dystrophy.A method for electrophysiological characterization of hamster retinal ganglion cells using a high-density CMOS microelectrode array.

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P2860

Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness.

http://www.wikidata.org/entity/Q41991320

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Virally delivered channelrhodo ...... ple mouse models of blindness.

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type

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Virally delivered channelrhodo ...... ple mouse models of blindness.

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Virally delivered channelrhodo ...... ple mouse models of blindness.

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Molecular Therapy

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Virally delivered channelrhodo ...... ple mouse models of blindness.

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P2093

A Cyrus Arman

http://www.w3.org/2001/XMLSchema#string

Alan Horsager

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Alapakkam P Sampath

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Benjamin C Matteo

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Edward S Boyden

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Gabriel M Gordon

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Jennifer A Lockridge

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Jianwen Liu

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Kenneth P Greenberg

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Kimberly A Silka

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P2860

Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration

Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial

Millisecond-timescale optical control of neural dynamics in the nonhuman primate brain

Millisecond-timescale, genetically targeted optical control of neural activity

Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN

Effect of gene therapy on visual function in Leber's congenital amaurosis

Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290) blindness: generation of an all-cone Nphp6 hypomorph mouse that mimics the human retinal ciliopathy

Organotypic culture of physiologically functional adult mammalian retinas.

High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors

Spatiotemporal interactions in retinal prosthesis subjects

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1220-1229

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scholarly article

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10.1038/MT.2011.69

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7

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19

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2011-04-19T00:00:00Z

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51063046

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21505421

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